{"id":"W3182028351","doi":"10.21203/rs.3.rs-647012/v1","title":"Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University Health Network; Princess Margaret Cancer Centre; Occupational Cancer Research Centre; Université Laval","funders":"Common Fund; National Human Genome Research Institute; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Cancer Prevention and Research Institute of Texas; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health","keywords":"Lung cancer; Genome-wide association study; Biology; Genotype; Expression quantitative trait loci; Genetic association; Sexual dimorphism; Oncology; Cancer; Gene; Genetics; Internal medicine; Single-nucleotide polymorphism; Medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001167108,0.0007190004,0.0008003875,0.001071113,0.0005356996,0.001296695,0.0006044515,0.0009244155,0.007013097],"category_scores_gemma":[0.004680778,0.0003695643,0.002651381,0.001798806,0.0003868157,0.0002936608,0.0007591857,0.001339848,0.0004804316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002229104,"about_ca_system_score_gemma":0.0004982976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006618395,"about_ca_topic_score_gemma":0.006013518,"domain_scores_codex":[0.9985917,0.0004587795,0.00009770251,0.0005020265,0.0001224902,0.000227244],"domain_scores_gemma":[0.9973387,0.001655108,0.0003169544,0.0002954704,0.000120307,0.0002734161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004797434,0.0001936454,0.9355582,0.000197014,0.0083974,0.001809524,0.0003213646,0.000913556,0.02710432,0.0008332043,0.001995885,0.01787852],"study_design_scores_gemma":[0.0001760846,0.000225415,0.9857898,0.00002527606,0.003983737,0.0009071993,0.0001668507,0.003793639,0.002160415,0.001568228,0.001170816,0.00003256902],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882694,0.001536647,0.004255685,0.0006708154,0.0001215801,0.00001471225,0.004028239,0.0001473278,0.0009555811],"genre_scores_gemma":[0.9967609,0.0001825003,0.001077282,0.00009370578,0.00005968562,0.00001372113,0.00102687,0.00004667973,0.0007386983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007013097,"threshold_uncertainty_score":0.02346122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02629420736648951,"score_gpt":0.3796430138127775,"score_spread":0.353348806446288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}