{"id":"W3182039670","doi":"10.1093/neuonc/noab178","title":"Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Medical Research Council; Brain Tumour Charity; CHILDREN with CANCER UK; Canadian Institutes of Health Research; National Institute for Health and Care Research; Action Medical Research; Cancer Research UK; C.R. Younger Foundation; Academy of Medical Sciences; JGW Patterson Foundation","keywords":"Medulloblastoma; Biology; Oncology; Wnt signaling pathway; Disease; Mutation; Genetic divergence; Internal medicine; Gene; Cohort; Genetics; Bioinformatics; Medicine; Genetic diversity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002341101,0.0001576201,0.0002891507,0.0004808552,0.0002078328,0.0004657564,0.0002321063,0.0002082874,0.0009202496],"category_scores_gemma":[0.000599763,0.0001147273,0.0001946973,0.0003837647,0.0002384601,0.0002818255,0.0004554235,0.00026351,0.0002262048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004484043,"about_ca_system_score_gemma":0.0002462383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001747238,"about_ca_topic_score_gemma":0.002124578,"domain_scores_codex":[0.9998153,0.00002057764,0.00001245201,0.00005562288,0.00004881263,0.00004727993],"domain_scores_gemma":[0.9996112,0.00003690348,0.0001963884,0.00003246785,0.00004023393,0.00008277967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006963691,0.00003833105,0.8966219,0.00004329792,0.00006973965,0.0005626943,0.0002890038,0.0002540466,0.08734645,0.0001584006,0.0001612247,0.0137585],"study_design_scores_gemma":[0.000004173291,0.0001228211,0.99343,0.000004859666,0.0000307801,0.001328225,0.0001411203,0.0002770977,0.004189833,0.00009120651,0.0003759844,0.000003981594],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993072,0.0001931404,0.0001181122,0.00001212554,7.014473e-7,0.000003404859,0.0001733333,0.00001423029,0.0001777715],"genre_scores_gemma":[0.9994175,0.00008535533,0.00009837848,0.000006745787,0.000001958861,0.00000366344,0.0002987761,0.00000457084,0.00008309437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001747238,"threshold_uncertainty_score":0.003474176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351053465576387,"score_gpt":0.2713937264407502,"score_spread":0.2578831917849864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}