{"id":"W3182039670","doi":"10.1093/neuonc/noab178","title":"Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Medical Research Council; Brain Tumour Charity; CHILDREN with CANCER UK; Canadian Institutes of Health Research; National Institute for Health and Care Research; Action Medical Research; Cancer Research UK; C.R. Younger Foundation; Academy of Medical Sciences; JGW Patterson Foundation","keywords":"Medulloblastoma; Biology; Oncology; Wnt signaling pathway; Disease; Mutation; Genetic divergence; Internal medicine; Gene; Cohort; Genetics; Bioinformatics; Medicine; Genetic diversity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003638158,0.00009656556,0.0002710858,0.00004984693,0.0000522475,0.000002136833,0.00003524466,0.00008389419,0.0006872804],"category_scores_gemma":[0.0001506191,0.00008543888,0.00005988794,0.0001473623,0.0001078119,0.00002351677,0.00008554052,0.00008829914,0.00003514924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009695316,"about_ca_system_score_gemma":0.0001453831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001693787,"about_ca_topic_score_gemma":0.00008960994,"domain_scores_codex":[0.9991632,0.00005776721,0.0001888465,0.0002787361,0.0001250099,0.0001864271],"domain_scores_gemma":[0.9993123,0.0001571348,0.00008643715,0.0002046659,0.0001148461,0.0001245941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001841405,0.0004985911,0.09788868,0.00004894682,0.00008657413,0.002665925,0.0002093479,0.00002219611,0.8655448,0.0002641521,0.02094893,0.01163772],"study_design_scores_gemma":[0.005273307,0.002690205,0.182387,0.00006179241,0.0003373483,0.003081518,0.0005198297,0.0002504085,0.5126041,0.0001607263,0.2924712,0.000162602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917773,0.0006773671,0.000009946554,0.00394158,0.0003749463,0.0001524478,0.000006657242,0.00001680135,0.003042956],"genre_scores_gemma":[0.9960876,0.001679851,0.001081344,0.0007730833,0.0000395423,0.00003153379,0.000006025694,0.00001282843,0.0002881799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3529407,"threshold_uncertainty_score":0.7525238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351053465576387,"score_gpt":0.2713937264407502,"score_spread":0.2578831917849864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}