{"id":"W3182093010","doi":"10.1016/j.ejphar.2021.174310","title":"NMDA and AMPA receptors dysregulation in Alzheimer's disease","year":2021,"lang":"en","type":"review","venue":"European Journal of Pharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":141,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Guilan University of Medical Sciences; University of Manitoba","keywords":"AMPA receptor; Long-term depression; Synaptic plasticity; Neuroscience; Neurodegeneration; Ion channel linked receptors; Excitotoxicity; NMDA receptor; Glutamate receptor; Silent synapse; Kainate receptor; Receptor; Long-term potentiation; Neurotransmission; Biology; Glutamatergic; Medicine; Internal medicine; Disease; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005769894,0.001118041,0.002012175,0.001417752,0.0002164609,0.0011186,0.001087701,0.001384603,0.003117226],"category_scores_gemma":[0.0005857518,0.0002689058,0.0004617669,0.001738262,0.0004052142,0.001156275,0.0006869583,0.001521268,0.002235319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005427871,"about_ca_system_score_gemma":0.00111565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217771,"about_ca_topic_score_gemma":0.002426525,"domain_scores_codex":[0.9998785,0.00001787688,0.00002808696,0.00002437279,0.00003832909,0.00001270601],"domain_scores_gemma":[0.9997757,0.00007479978,0.00004711808,0.000006066817,0.0000717037,0.00002456288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002446956,0.00009189991,0.0002488554,0.01721574,0.0001620557,0.000349882,0.00003984896,0.0002535406,0.001602696,0.001812102,0.03607626,0.9419024],"study_design_scores_gemma":[0.000133617,0.0002624077,0.003044726,0.007502054,0.0007925695,0.002879495,0.0001090774,0.0002107406,0.0007632438,0.004114932,0.9801396,0.00004745135],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008661659,0.9990535,0.00006506298,0.0002084642,0.0001904637,0.000002855632,0.00001612796,0.000005007496,0.0003718818],"genre_scores_gemma":[0.0004878165,0.9986715,0.0001142175,0.0001338054,0.0002606565,0.000004303036,0.00002621109,7.455033e-7,0.0003007722],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003117226,"threshold_uncertainty_score":0.01042819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1431751835042187,"score_gpt":0.4272132667078847,"score_spread":0.284038083203666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}