{"id":"W3182095224","doi":"10.1038/s43018-021-00220-w","title":"Transcriptional control of CBX5 by the RNA-binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia","year":2021,"lang":"en","type":"article","venue":"Nature Cancer","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Myeloid leukemia; Chromatin; Biology; RNA-binding protein; Transcription factor; Myeloid; Transcription (linguistics); Leukemia; Cancer research; Cell biology; Transcriptional regulation; RNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002112203,0.0001380742,0.0001595321,0.0002068232,0.0002868642,0.0004829993,0.0002682096,0.0001793627,0.001034236],"category_scores_gemma":[0.0001985343,0.000120355,0.0001275105,0.0001155487,0.000381098,0.0001873682,0.0002754587,0.0004409369,0.0003486584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006489782,"about_ca_system_score_gemma":0.0001864327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001170194,"about_ca_topic_score_gemma":0.001831406,"domain_scores_codex":[0.9998646,0.00002446486,0.000009406513,0.00003093046,0.000038169,0.00003249996],"domain_scores_gemma":[0.9998826,0.00002104405,0.00002873883,0.00002024117,0.00001027302,0.00003711945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009706055,0.000006775462,0.0004981716,0.000008786482,0.00000158787,0.00002817416,0.0000264249,0.00007558852,0.9973901,0.0005337006,0.00004155908,0.001292092],"study_design_scores_gemma":[0.00001478663,0.0000678208,0.01543101,0.000006171712,0.000006457871,0.0001150222,0.0000646382,0.00151843,0.9802456,0.0002266264,0.002297236,0.000006121541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965537,0.0008171102,0.0013575,0.0001099715,0.00001054402,0.000003196019,0.000120037,0.00006728282,0.000960711],"genre_scores_gemma":[0.9984384,0.00008822874,0.0003801221,0.00002352691,0.000002905129,0.00000279257,0.0001254517,0.00001722453,0.0009213236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001170194,"threshold_uncertainty_score":0.004708648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00480444394237915,"score_gpt":0.2595396345002008,"score_spread":0.2547351905578216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}