{"id":"W3182188484","doi":"10.12688/gatesopenres.13304.2","title":"A multi-center, adaptive, randomized, platform trial to evaluate the effect of repurposed medicines in outpatients with early coronavirus disease 2019 (COVID-19) and high-risk for complications: the TOGETHER master trial protocol","year":2021,"lang":"en","type":"preprint","venue":"Gates Open Research","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McMaster University","funders":"Rainwater Charitable Foundation; Fast Grants; Bill and Melinda Gates Foundation","keywords":"Medicine; Randomized controlled trial; Interim analysis; Clinical endpoint; Clinical trial; Placebo; Surrogate endpoint; Adverse effect; Internal medicine; Intensive care medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.03221597,0.0005161643,0.002294568,0.0003730739,0.0004828256,0.0003348014,0.001655644,0.000220613,0.00007703904],"category_scores_gemma":[0.1555862,0.0002276421,0.0003848494,0.0005712178,0.001766375,0.0001230271,0.005142672,0.001898507,0.00000993121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000422469,"about_ca_system_score_gemma":0.002655868,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01412881,"about_ca_topic_score_gemma":0.001152646,"domain_scores_codex":[0.9872091,0.006427632,0.001564766,0.001438729,0.002533669,0.0008260478],"domain_scores_gemma":[0.9308605,0.06399839,0.0005332752,0.002199564,0.001618774,0.0007894628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9745173,0.001190311,0.01195499,0.001699708,0.0008428505,0.00002357459,0.00120736,0.0001419543,0.00001061907,0.00001795405,0.0003408297,0.008052493],"study_design_scores_gemma":[0.9629165,0.01461463,0.01318473,0.002121929,0.000409999,5.444371e-7,0.0002070789,0.004002551,0.00003206378,0.000580241,0.001692384,0.0002373764],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.3399494,0.0002074241,0.0006983435,0.01583694,0.0001383734,0.6426896,0.0004242403,0.00001858785,0.0000370623],"genre_scores_gemma":[0.2429453,0.0002281058,0.0009455756,0.0006828954,0.0002242031,0.7541515,0.0001402478,0.00007758894,0.0006045365],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1233702,"threshold_uncertainty_score":0.9965373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3580817163623536,"score_gpt":0.5610205126817674,"score_spread":0.2029387963194139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}