{"id":"W3182197846","doi":"10.1016/j.jbc.2021.100966","title":"Structural details of monoclonal antibody m971 recognition of the membrane-proximal domain of CD22","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Research Chairs; National Research Council Canada; Canada Foundation for Innovation; University of Saskatchewan; Canadian Light Source","keywords":"CD22; Epitope; Antibody; SIGLEC; Antigen; Sialic acid; Paratope; Monoclonal antibody; Chemistry; B cell; Molecular biology; Receptor; Biology; Cell biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009660472,0.0002963035,0.0002553875,0.0001577121,0.0002790563,0.0002774868,0.000594293,0.000335267,0.001753179],"category_scores_gemma":[0.0001674039,0.0001736709,0.0002182587,0.0001943237,0.0001525376,0.0001667302,0.000202465,0.0007118101,0.0005372966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006258813,"about_ca_system_score_gemma":0.0003370669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003056522,"about_ca_topic_score_gemma":0.002168073,"domain_scores_codex":[0.9998912,0.00001448411,0.000004916179,0.0000166812,0.00004561335,0.00002713861],"domain_scores_gemma":[0.9999458,0.00001136789,0.00001235802,0.000003852221,0.00001126247,0.00001542959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004675135,0.0001801159,0.002191553,0.0001952154,0.00005038405,0.001076301,0.0001389035,0.004692359,0.9781308,0.002529918,0.002066651,0.008280437],"study_design_scores_gemma":[0.0002794054,0.0008246276,0.01807522,0.0000715779,0.0001772986,0.002493731,0.0003387719,0.0590095,0.8617697,0.001426148,0.05545466,0.00007928476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879172,0.003061577,0.004112455,0.0003042929,0.00005952748,0.00002885842,0.0005799274,0.0001092811,0.003826913],"genre_scores_gemma":[0.9902397,0.001815505,0.003585853,0.0001841699,0.0000176172,0.00002111263,0.001976204,0.00002053685,0.002139251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003056522,"threshold_uncertainty_score":0.006077468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05146629139449396,"score_gpt":0.3259368382482185,"score_spread":0.2744705468537245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}