{"id":"W3182312709","doi":"10.1158/1538-7445.am2021-517","title":"Abstract 517: Tebentafusp induces transient systemic inflammation and modifies the micro-environment to sensitize uveal melanoma tumors to cytotoxic CD8 cells","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Melanoma; CD8; Immune system; Chemokine; Cytotoxic T cell; Immunohistochemistry; Inflammation; CD3; T cell; Immunology; CXCL9; Cancer research; Internal medicine; Biology; CXCL10","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001359959,0.000267615,0.0002594641,0.0001004767,0.0001184729,0.0001420988,0.0001188388,0.0001875437,0.002803868],"category_scores_gemma":[0.00009920663,0.0000749295,0.0001567921,0.0001010287,0.0001485093,0.00008026202,0.00008231242,0.0005164386,0.0003735747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002340184,"about_ca_system_score_gemma":0.0002112825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005003524,"about_ca_topic_score_gemma":0.0008493375,"domain_scores_codex":[0.9999298,0.00001491172,0.00000443303,0.00001435201,0.00001452038,0.00002194795],"domain_scores_gemma":[0.9999503,0.00001189293,0.00001105423,0.00000684151,0.000005647129,0.00001425129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002443113,0.0005411969,0.001990103,0.00007741559,0.00002040519,0.00009989558,0.00002366195,0.0002433578,0.983691,0.0000367076,0.0005288288,0.01030437],"study_design_scores_gemma":[0.001492722,0.04575351,0.08320618,0.0000170652,0.0001029391,0.001601294,0.00005224004,0.002320466,0.8599001,0.00006607565,0.005477922,0.000009541185],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.997946,0.0005008259,0.0003655912,0.00004647571,0.0000152424,0.00004349233,0.0003265872,0.00002806833,0.0007277964],"genre_scores_gemma":[0.9973556,0.0002618144,0.0003631334,0.00006516757,0.00002249109,0.00004889967,0.0007659536,0.000006707255,0.001110229],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002803868,"threshold_uncertainty_score":0.009379864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04375356368309628,"score_gpt":0.3430175349719414,"score_spread":0.2992639712888451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}