{"id":"W3182408948","doi":"10.1158/1078-0432.ccr-20-4607","title":"Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Medical Research Council; Canada Digital Adoption Program; National Research Foundation","keywords":"T790M; Transcriptome; Biology; Cancer research; Exome; EGFR inhibitors; Gene expression profiling; Exome sequencing; Genetics; Gene; Bioinformatics; KRAS; Epidermal growth factor receptor; Mutation; Cancer; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338371,0.0001288921,0.0001897205,0.0002640412,0.0001614705,0.0002602306,0.00009717989,0.0001607371,0.0006364222],"category_scores_gemma":[0.0002349783,0.00006824744,0.0001734793,0.0002433625,0.0001177866,0.000111792,0.0002321094,0.0001631027,0.0001986341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001501342,"about_ca_system_score_gemma":0.0001466535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005074941,"about_ca_topic_score_gemma":0.001259003,"domain_scores_codex":[0.9999313,0.000008694113,0.000004747145,0.00002313174,0.00001926446,0.00001277428],"domain_scores_gemma":[0.9999288,0.00001730825,0.00002262572,0.000007239743,0.00001231792,0.00001171623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004085695,0.00003330633,0.09737676,0.0000759957,0.00004035874,0.0002781433,0.0001198092,0.0003898531,0.8886367,0.0001172452,0.0001310057,0.01239215],"study_design_scores_gemma":[0.000017495,0.0003799578,0.8750222,0.00001922616,0.00009262492,0.001813362,0.0003220198,0.004967221,0.1142706,0.0004645047,0.002620335,0.0000104712],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976528,0.000337945,0.0009557884,0.00003292071,0.000001896179,0.00001085583,0.0006412522,0.00001405493,0.0003525603],"genre_scores_gemma":[0.9971417,0.0001995391,0.0009006082,0.00004095524,0.000003434046,0.00001633491,0.001382857,0.000008294939,0.0003063835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006364222,"threshold_uncertainty_score":0.002129078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3480102590733958,"score_gpt":0.5620181373188999,"score_spread":0.2140078782455042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}