{"id":"W3182629320","doi":"10.1017/cjn.2019.163","title":"P.063 SUNFISH Part 1 results and Part 2 trial design in patients with type 2/3 spinal muscular atrophy (SMA) receiving risdiplam (RG7916)","year":2019,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"SMN1; SMA*; Spinal muscular atrophy; Tolerability; Medicine; Adverse effect; Internal medicine; Placebo; Pharmacodynamics; Oncology; Pharmacokinetics; Pharmacology; Disease; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.004825432,0.0003244441,0.000634304,0.0009266202,0.0008876841,0.0003994026,0.0008762213,0.000184115,0.000134751],"category_scores_gemma":[0.002518044,0.0002070349,0.0001519069,0.001464878,0.003730811,0.0005319864,0.00006711185,0.001327002,0.000004511415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001488486,"about_ca_system_score_gemma":0.003495282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000466653,"about_ca_topic_score_gemma":0.009450898,"domain_scores_codex":[0.9946653,0.001176847,0.0009283778,0.0007040269,0.00119079,0.001334709],"domain_scores_gemma":[0.9966662,0.0003672557,0.0005095858,0.0002129523,0.000528862,0.001715131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01733106,0.00009764079,0.9749194,0.00001531774,0.00002378443,0.002803972,0.0001256324,0.0009799226,0.00001468647,0.00004481898,0.0003792388,0.003264512],"study_design_scores_gemma":[0.01223543,0.3380163,0.6408837,0.0001562189,0.00005958443,0.003585125,0.0001646082,0.0003590107,0.00002755983,0.0007572841,0.003419427,0.0003357115],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950358,0.00074447,0.000008767551,0.001815844,0.0007154669,0.0006906407,0.000006299398,0.000009707094,0.0009730017],"genre_scores_gemma":[0.9970638,0.0005109307,0.0009505468,0.001225075,0.0001964872,0.000003471436,8.395157e-7,0.0000156265,0.00003317988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3379187,"threshold_uncertainty_score":0.9989805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03959955267806798,"score_gpt":0.2799191363844825,"score_spread":0.2403195837064145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}