{"id":"W3182709241","doi":"10.1101/2021.07.08.450798","title":"FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"FANCD2; Nuclease; RAD51; Homologous recombination; Cell biology; Biology; DNA; Recombinase; FANCA; DNA repair; Molecular biology; Genetics; Gene; Fanconi anemia; Recombination","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003083475,0.000343521,0.0001625889,0.0001748745,0.000129226,0.0003143687,0.0002965121,0.0002759752,0.001798408],"category_scores_gemma":[0.0001311638,0.0001512723,0.0002053344,0.00007647109,0.0002577812,0.0001951975,0.0002083601,0.0003608416,0.0002950848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004110076,"about_ca_system_score_gemma":0.000265183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004205223,"about_ca_topic_score_gemma":0.0006447549,"domain_scores_codex":[0.9998121,0.00003551694,0.00001604336,0.0000453997,0.0000515099,0.00003950124],"domain_scores_gemma":[0.9999082,0.00001744638,0.00001752121,0.0000139994,0.00001094288,0.00003185758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005893859,0.00002249619,0.0002723762,0.0000226818,0.000007424047,0.00003809904,0.000004029519,0.00008196387,0.9985622,0.0002715774,0.00006219625,0.0005962492],"study_design_scores_gemma":[0.00002028823,0.0001062176,0.002012098,0.000002579589,0.000009281365,0.0001766115,0.000006135438,0.001523742,0.9939375,0.0000575221,0.002146408,0.000001597854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848541,0.003414296,0.007802498,0.0002183327,0.0000599331,0.00003444991,0.0001881017,0.0001741647,0.00325414],"genre_scores_gemma":[0.9918061,0.0003314913,0.002956568,0.00006841167,0.0000139052,0.00002901831,0.0002896126,0.00001247606,0.004492344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001798408,"threshold_uncertainty_score":0.006016314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01250905727086456,"score_gpt":0.2225197785356697,"score_spread":0.2100107212648052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}