{"id":"W318276992","doi":"10.1038/ncomms8250","title":"LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Cancer Research Society; National Science Foundation","keywords":"mTORC1; RHEB; Lysosome; Cell biology; Transporter; Chemistry; Autophagy; Biochemistry; Biology; PI3K/AKT/mTOR pathway; Signal transduction; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002051729,0.00009645523,0.00007688603,0.00003128669,0.0001481196,0.00002522512,0.0003718736,0.0002135736,0.000004033008],"category_scores_gemma":[0.00006184608,0.00007358469,0.00003987907,0.0001259816,0.00007141279,0.000007911047,0.00006130536,0.0002664468,0.000004280932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001116796,"about_ca_system_score_gemma":0.00004892288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001970899,"about_ca_topic_score_gemma":0.0006269721,"domain_scores_codex":[0.9994414,0.0000616738,0.0001234705,0.000164297,0.0001026648,0.0001064755],"domain_scores_gemma":[0.9988993,0.00002079444,0.00003942522,0.0008314293,0.0001303174,0.00007869294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000113509,0.0001309634,0.0190746,0.00001374855,0.00008937225,6.286443e-7,0.002308074,0.00002160722,0.9653822,0.004438329,0.003148965,0.005278065],"study_design_scores_gemma":[0.0004727527,0.0001452653,0.03331356,0.00002450706,0.00004649268,0.000007901938,0.0003026619,0.00007148077,0.05617329,0.0004194242,0.9087909,0.0002316931],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720278,0.005527668,0.003728087,0.01442536,0.0001083619,0.0006286738,0.00002699731,0.00003765864,0.003489439],"genre_scores_gemma":[0.9958946,0.0003236747,0.0009240041,0.0006667479,0.000081235,0.00004612282,0.001669957,0.00001383147,0.0003798808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9092088,"threshold_uncertainty_score":0.3000697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03463902986186239,"score_gpt":0.2885640621306672,"score_spread":0.2539250322688048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}