{"id":"W3182809132","doi":"","title":"Dual angiopoietin-2 and VEGF-A inhibition with faricimab in neovascular age-related macular degeneration: phase 3 TENAYA and LUCERNE trial design","year":2021,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Macular degeneration; Angiopoietin receptor; VEGF receptors; Angiopoietin 2; Angiopoietin; Medicine; Ophthalmology; Vascular endothelial growth factor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003719483,0.002601607,0.003355912,0.0005439431,0.0005571317,0.001885098,0.001108033,0.001747567,0.006800353],"category_scores_gemma":[0.001643687,0.0007214373,0.00309297,0.0004828033,0.001531634,0.00150887,0.0005060609,0.003513872,0.001217461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001281357,"about_ca_system_score_gemma":0.002015759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00181762,"about_ca_topic_score_gemma":0.003749136,"domain_scores_codex":[0.9989848,0.0004687369,0.00004287541,0.0001624123,0.00006480245,0.000276479],"domain_scores_gemma":[0.999317,0.0001379551,0.0001265656,0.00006536128,0.00004756346,0.0003055965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9645845,0.007362467,0.0007152091,0.0005875434,0.001519913,0.00006177351,0.00008361948,0.0008125342,0.003437948,0.0004565217,0.001834912,0.01854306],"study_design_scores_gemma":[0.9519005,0.04422088,0.001042159,0.0000320119,0.0006024282,0.0000364001,0.00002442655,0.0003973696,0.0002992025,0.0003403867,0.001084896,0.00001925078],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.96297,0.01079237,0.003160547,0.002141153,0.001102395,0.009859904,0.003085999,0.0003711969,0.006516489],"genre_scores_gemma":[0.9635198,0.004343731,0.004281963,0.002936605,0.0006079187,0.0130404,0.001882444,0.00009004549,0.009296908],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.006800353,"threshold_uncertainty_score":0.02274942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04326070063782073,"score_gpt":0.3416679687160972,"score_spread":0.2984072680782764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}