{"id":"W3182833340","doi":"10.1093/braincomms/fcab139","title":"Serum metabolites associated with brain amyloid beta deposition, cognition and dementia progression","year":2021,"lang":"en","type":"article","venue":"Brain Communications","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Alzheimer's disease; Neuroimaging; Amyloid (mycology); Cognitive decline; Internal medicine; Medicine; Psychology; Metabolite; Disease; Endocrinology; Pathology; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002174219,0.0001458861,0.0001512457,0.00007596504,0.0007351335,0.000170025,0.0003754954,0.00007110716,0.00007332883],"category_scores_gemma":[0.001253309,0.000136192,0.00004242581,0.00062187,0.0003409165,0.0002754591,0.0003051844,0.0002018154,0.00001449473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001612108,"about_ca_system_score_gemma":0.00008514354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005265635,"about_ca_topic_score_gemma":0.0002933324,"domain_scores_codex":[0.9982943,0.0006978877,0.0002189794,0.0003278714,0.0002246858,0.0002362676],"domain_scores_gemma":[0.9975008,0.001341745,0.0001364718,0.0007981535,0.0001314026,0.00009139605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002674418,0.001025545,0.004173462,0.00003132979,0.0001274524,0.00001532606,0.0009336508,0.000004986283,0.9383733,0.02692809,0.004445201,0.0239149],"study_design_scores_gemma":[0.003689867,0.0001940004,0.1390937,0.0004487025,0.0002142332,0.0001101191,0.001036746,0.001520898,0.818364,0.007453753,0.02707489,0.0007991263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8518246,0.006616038,0.001611862,0.1207597,0.00009357466,0.001084471,0.0003066265,0.0006003093,0.01710282],"genre_scores_gemma":[0.991321,0.0003050849,0.002618152,0.005058212,0.00001216175,0.00009068483,0.0002582665,0.00002441371,0.0003120722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1394964,"threshold_uncertainty_score":0.5654127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03270832274710121,"score_gpt":0.2948260422334531,"score_spread":0.2621177194863519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}