{"id":"W3182833340","doi":"10.1093/braincomms/fcab139","title":"Serum metabolites associated with brain amyloid beta deposition, cognition and dementia progression","year":2021,"lang":"en","type":"article","venue":"Brain Communications","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Alzheimer's disease; Neuroimaging; Amyloid (mycology); Cognitive decline; Internal medicine; Medicine; Psychology; Metabolite; Disease; Endocrinology; Pathology; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004338279,0.0003731298,0.0003148753,0.0005845056,0.0002359963,0.0005343619,0.0001554877,0.0003046031,0.001012923],"category_scores_gemma":[0.001161389,0.0001584364,0.0004042349,0.0006595204,0.0001252851,0.0002035028,0.0002618049,0.0003676756,0.0001214776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001844948,"about_ca_system_score_gemma":0.0002286455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002935024,"about_ca_topic_score_gemma":0.002323039,"domain_scores_codex":[0.9998658,0.00003168892,0.00001663568,0.00003815274,0.00002719528,0.00002046214],"domain_scores_gemma":[0.9994243,0.00009490211,0.0002678843,0.00004723215,0.00007545006,0.00009030595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001787535,0.00007956308,0.9895594,0.00002462395,0.00038178,0.0001419193,0.00003648848,0.0001592443,0.004624547,0.00002772831,0.0001282182,0.003049],"study_design_scores_gemma":[0.00001489486,0.0001371594,0.9984826,0.000002409188,0.00009998699,0.0002021529,0.00002213501,0.0003248191,0.0005752205,0.00004692413,0.00008848638,0.000003214975],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99856,0.0003716827,0.0002052244,0.00002537306,0.000006199475,0.000005714928,0.000565962,0.000014285,0.0002454236],"genre_scores_gemma":[0.9990556,0.00007812876,0.0002381549,0.00001245509,0.00000607259,0.00000522344,0.0003916039,0.000002589929,0.0002101694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002935024,"threshold_uncertainty_score":0.005835891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03270832274710121,"score_gpt":0.2948260422334531,"score_spread":0.2621177194863519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}