{"id":"W3182894010","doi":"10.1158/1538-7445.am2021-1518","title":"Abstract 1518: Dose optimization and radiation dosimetry of CD45-targeting 225Actinium-armed antibody as a conditioning agent for adoptive cell therapy","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Medicine; Bone marrow; Immune system; Stem cell; Adoptive cell transfer; Antibody; Total body irradiation; Haematopoiesis; Immunology; White blood cell; Transplantation; Chemotherapy; Radioimmunotherapy; Dosimetry; Cancer research; T cell; Nuclear medicine; Internal medicine; Cyclophosphamide; Biology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002550161,0.0003420002,0.0002133521,0.0002816716,0.00008529289,0.0002002247,0.0002067842,0.0002301779,0.0007064349],"category_scores_gemma":[0.0001107666,0.0001173574,0.0002047287,0.0002356457,0.0001850475,0.00009604305,0.0001219103,0.0002507253,0.0001383271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003119049,"about_ca_system_score_gemma":0.0001620577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007629076,"about_ca_topic_score_gemma":0.0005756543,"domain_scores_codex":[0.999842,0.00002483667,0.000009436922,0.00003437927,0.00006669154,0.00002254695],"domain_scores_gemma":[0.9999247,0.00001381347,0.00002950887,0.00001022987,0.00001294046,0.000008779097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000183166,0.00005524326,0.0005808609,0.00003710916,0.00001024494,0.00001440878,0.00002309108,0.00213533,0.9940006,0.00009721594,0.00005723921,0.002805638],"study_design_scores_gemma":[0.00001037225,0.0005514324,0.001613859,0.000002136848,0.00002230032,0.00004339731,0.000006088661,0.00235998,0.994733,0.00001243682,0.000641504,0.000003587233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877102,0.001288408,0.008927149,0.00003295044,0.00001215514,0.00005603371,0.0001367088,0.00008131611,0.001755041],"genre_scores_gemma":[0.9928626,0.0003997239,0.005481215,0.0000164519,0.000003231184,0.00002841984,0.0001535873,0.00002748296,0.001027284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007629076,"threshold_uncertainty_score":0.002363265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04023117044653529,"score_gpt":0.4184501450814923,"score_spread":0.378218974634957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}