{"id":"W3182898074","doi":"10.1038/s41586-021-03791-x","title":"Systems vaccinology of the BNT162b2 mRNA vaccine in humans","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":575,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Division of Undergraduate Education; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Emory University; Parker Institute for Cancer Immunotherapy; Georgia Clinical and Translational Science Alliance; Open Philanthropy Project; Parker Foundation","keywords":"Innate immune system; Vaccination; CD14; Immune system; Immunology; Biology; Antibody; Virology; Acquired immune system; CD16; CD8; Medicine; CD3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008971388,0.0002635547,0.0002254082,0.0001580554,0.0002203785,0.0004795397,0.0002236999,0.0004651346,0.002503554],"category_scores_gemma":[0.000313481,0.0001023442,0.000227115,0.00007558745,0.0004989426,0.000351827,0.0002421684,0.00049374,0.0005222806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006845219,"about_ca_system_score_gemma":0.0005641669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009332858,"about_ca_topic_score_gemma":0.0004882351,"domain_scores_codex":[0.9997745,0.0001067287,0.000007821076,0.00004145204,0.00002809379,0.00004127028],"domain_scores_gemma":[0.9999338,0.00001676494,0.00001301361,0.00001729196,0.000008897449,0.00001014543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003745662,0.001626401,0.009192643,0.0005209208,0.0001012627,0.0006106531,0.0003702622,0.001358353,0.8203999,0.01407997,0.007368583,0.1406255],"study_design_scores_gemma":[0.001770653,0.05544526,0.05198326,0.0004913402,0.000326407,0.005426848,0.00107143,0.008739683,0.6694558,0.0105319,0.1947024,0.00005510584],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9397574,0.0133535,0.01261147,0.003162144,0.0008294131,0.0005543193,0.0006625782,0.0002299218,0.02883924],"genre_scores_gemma":[0.987821,0.003840091,0.002525556,0.0005852045,0.0001004969,0.0002005861,0.0005210373,0.00001624207,0.004389739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002503554,"threshold_uncertainty_score":0.008375168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253941895251952,"score_gpt":0.3440369323880227,"score_spread":0.3214975134355031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}