{"id":"W3182898074","doi":"10.1038/s41586-021-03791-x","title":"Systems vaccinology of the BNT162b2 mRNA vaccine in humans","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":575,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Division of Undergraduate Education; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Emory University; Parker Institute for Cancer Immunotherapy; Georgia Clinical and Translational Science Alliance; Open Philanthropy Project; Parker Foundation","keywords":"Innate immune system; Vaccination; CD14; Immune system; Immunology; Biology; Antibody; Virology; Acquired immune system; CD16; CD8; Medicine; CD3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001929648,0.0000920019,0.000281309,0.0001081409,0.00003013382,0.000008094997,0.0001987998,0.0007926505,0.00002776194],"category_scores_gemma":[0.0006136764,0.0000592153,0.00008644402,0.0005769859,0.00001802092,0.00001820937,0.00010782,0.002103393,0.00001579923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007223302,"about_ca_system_score_gemma":0.0002730042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001146132,"about_ca_topic_score_gemma":0.0003214048,"domain_scores_codex":[0.9989465,0.00009589659,0.0002069754,0.0002147444,0.0003088966,0.0002270102],"domain_scores_gemma":[0.9990724,0.00008974345,0.00004907279,0.0005080398,0.0002651163,0.00001565688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001923278,0.0002381522,0.8067442,0.0004285935,0.00008487956,0.0003355096,0.0002689396,0.000002089154,0.1740322,0.004730029,0.01211835,0.0008247922],"study_design_scores_gemma":[0.00281233,0.0001092296,0.3787373,0.0002693,0.00003963651,0.0000973987,0.0003752558,0.00008980725,0.1809538,0.0002422676,0.4361658,0.0001079669],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975917,0.01180948,0.000001659131,0.002186999,0.0006620458,0.0002526832,0.000005242436,0.00001915775,0.009145694],"genre_scores_gemma":[0.9829375,0.00001415379,0.00001141965,0.01635639,0.000249065,0.00001160721,0.000002292124,0.00001314934,0.0004043804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4280069,"threshold_uncertainty_score":0.9138312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253941895251952,"score_gpt":0.3440369323880227,"score_spread":0.3214975134355031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}