{"id":"W3182911784","doi":"10.14740/jmc3710","title":"Transformation From Adenocarcinoma to Pleomorphic Carcinoma as an Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors","year":2021,"lang":"en","type":"article","venue":"Journal of Medical Cases","topic":"Metastasis and carcinoma case studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Gefitinib; T790M; Medicine; Erlotinib; Epidermal growth factor receptor; Adenocarcinoma; Lung cancer; Cancer research; Carcinoma; Tyrosine kinase; Pathology; Cancer; Internal medicine; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002446579,0.0005925716,0.0004404553,0.0008318849,0.0006656804,0.0008684273,0.0004721993,0.001185326,0.001985787],"category_scores_gemma":[0.001456463,0.0004042074,0.0005141005,0.0006349243,0.0007479165,0.0006541964,0.000576222,0.0009392336,0.0005534458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000437452,"about_ca_system_score_gemma":0.0002736137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00118412,"about_ca_topic_score_gemma":0.001709286,"domain_scores_codex":[0.9996595,0.00005907802,0.00002988885,0.00007134092,0.00006300216,0.0001170697],"domain_scores_gemma":[0.9993566,0.0001181792,0.0001334108,0.0001420154,0.0000602549,0.0001895481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001261762,0.00005343687,0.02306755,0.00004196933,0.0000132881,0.9678919,0.0001986871,0.0000698799,0.005074138,0.0002963235,0.0002010233,0.002965659],"study_design_scores_gemma":[0.00002998591,0.0001103243,0.01904871,0.000006604442,0.00001992962,0.9772391,0.0001331375,0.0004714516,0.001506316,0.0001773699,0.001249535,0.00000749119],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990073,0.001170473,0.001196913,0.0003667653,0.00004892534,0.0001054395,0.00007191202,0.00009336598,0.006873237],"genre_scores_gemma":[0.9987687,0.000246512,0.0002265704,0.00007530736,0.00004799453,0.000007154461,0.000036045,0.000006744224,0.0005848645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001985787,"threshold_uncertainty_score":0.006643116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04181060168360786,"score_gpt":0.3009486580847135,"score_spread":0.2591380564011057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}