{"id":"W3182911784","doi":"10.14740/jmc3710","title":"Transformation From Adenocarcinoma to Pleomorphic Carcinoma as an Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors","year":2021,"lang":"en","type":"article","venue":"Journal of Medical Cases","topic":"Metastasis and carcinoma case studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Gefitinib; T790M; Medicine; Erlotinib; Epidermal growth factor receptor; Adenocarcinoma; Lung cancer; Cancer research; Carcinoma; Tyrosine kinase; Pathology; Cancer; Internal medicine; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007987766,0.0003200003,0.0009956934,0.0002834666,0.0001631495,0.00006560479,0.0002356277,0.0001967576,0.002840047],"category_scores_gemma":[0.004920051,0.0002501864,0.0003365361,0.0005552453,0.00009921296,0.0003165579,0.0000861149,0.0003944722,0.00006749834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001946259,"about_ca_system_score_gemma":0.0008463404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001951123,"about_ca_topic_score_gemma":0.0002851722,"domain_scores_codex":[0.9951812,0.0003316662,0.001277961,0.0003825601,0.002386405,0.0004402162],"domain_scores_gemma":[0.9960354,0.000392682,0.0002935346,0.0003441435,0.001006269,0.001927955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.02175928,0.004433462,0.1777418,0.001731753,0.001610139,0.1706424,0.02799417,0.000008241452,0.1823878,0.002246855,0.3410529,0.06839112],"study_design_scores_gemma":[0.01030138,0.007057222,0.5056033,0.002946845,0.001050294,0.01067079,0.01233134,0.00002870074,0.3811307,0.0001881913,0.06769373,0.0009976058],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9497564,0.006948986,0.0003496907,0.04145031,0.0008294686,0.000280867,0.0002059221,0.00002252241,0.0001557693],"genre_scores_gemma":[0.9902049,0.0002787337,0.001680881,0.005487507,0.00205715,0.00001292606,0.00006963935,0.00003755464,0.0001706533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3278615,"threshold_uncertainty_score":0.9999951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04181060168360786,"score_gpt":0.3009486580847135,"score_spread":0.2591380564011057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}