{"id":"W3182953012","doi":"10.1016/j.jmb.2021.167145","title":"Biochemical Insight into Novel Rab-GEF Activity of the Mammalian TRAPPIII Complex","year":2021,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Michael Smith Health Research BC","keywords":"Rab; GTPase; Guanine nucleotide exchange factor; Chemistry; Cell biology; Biochemistry; Protein subunit; Vesicular transport protein; Membrane; Biophysics; Biology; Vesicle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002631741,0.0003632012,0.0002393703,0.0003977714,0.0004077107,0.0006880803,0.0003813444,0.00037441,0.0009476325],"category_scores_gemma":[0.0001930973,0.0002281627,0.0002587973,0.0002198859,0.0002669895,0.000420123,0.0002233446,0.0006576683,0.0003942992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009647401,"about_ca_system_score_gemma":0.0003237397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008396652,"about_ca_topic_score_gemma":0.001043604,"domain_scores_codex":[0.9999272,0.00001080388,0.000009358576,0.00001680816,0.00002004532,0.00001577949],"domain_scores_gemma":[0.9999046,0.00001937233,0.00001221564,0.00001156604,0.00001952643,0.00003265652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008737639,0.000009353521,0.000130344,0.00005111412,0.00000795114,0.0002651274,0.00002529351,0.00007332458,0.9973181,0.001000431,0.00006991845,0.000961661],"study_design_scores_gemma":[0.00001360208,0.00004898839,0.002403782,0.000007871093,0.00002903717,0.001415363,0.0000439289,0.001970116,0.9858889,0.0003485704,0.007817971,0.00001189152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685858,0.008981066,0.01589419,0.001137871,0.0001058567,0.00004335651,0.0007104957,0.0002548987,0.004286397],"genre_scores_gemma":[0.9856707,0.002668507,0.00682885,0.0001292284,0.00002642337,0.00002532778,0.000969982,0.00003296473,0.003648089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009647401,"threshold_uncertainty_score":0.006999731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464590219008477,"score_gpt":0.2543124181453437,"score_spread":0.2396665159552589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}