{"id":"W3182960513","doi":"10.1158/1538-7445.am2021-lb189","title":"Abstract LB189: Three-dimensional genome organization maps in normal haematopoietic stem cells and acute myeloid leukemia","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Newfoundland and Labrador Centre for Applied Health Research; Government of Newfoundland and Labrador; Memorial University of Newfoundland","funders":"","keywords":"Myeloid leukemia; Haematopoiesis; Biology; Cancer research; Stem cell; Epigenetics; Leukemia; Myeloid; Acute leukemia; Chromatin; Myelopoiesis; Oncogene; Cancer; Genetics; Gene; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006687117,0.0002522877,0.0002022052,0.001058066,0.0004047515,0.0005597427,0.0003059442,0.0002952613,0.007781839],"category_scores_gemma":[0.0001223323,0.0002272381,0.0003704316,0.0009086762,0.0001706281,0.0002073294,0.0004236733,0.0004740554,0.002949486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004668158,"about_ca_system_score_gemma":0.0002427526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002709138,"about_ca_topic_score_gemma":0.003015886,"domain_scores_codex":[0.9998976,0.000006723895,0.000005424796,0.00003092514,0.00004449094,0.00001483892],"domain_scores_gemma":[0.999934,0.000008351664,0.00002181488,0.000007687459,0.00001077219,0.00001750094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000280757,0.00002737754,0.002699075,0.0001819762,0.00001911632,0.0002882857,0.000143418,0.0006756939,0.9639342,0.002106343,0.004140248,0.02550354],"study_design_scores_gemma":[0.00007367555,0.0001750441,0.09837139,0.00009692258,0.00008265266,0.001927711,0.0003093045,0.01219294,0.686354,0.002740863,0.1975972,0.0000782889],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7997957,0.00462576,0.1017047,0.001205072,0.0003799438,0.0001826812,0.0488093,0.009524993,0.03377177],"genre_scores_gemma":[0.8242004,0.001994884,0.08436745,0.0002974124,0.00005105262,0.0002770014,0.0556474,0.001256459,0.03190785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007781839,"threshold_uncertainty_score":0.02603281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02703654494666958,"score_gpt":0.3116109471167089,"score_spread":0.2845744021700393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}