{"id":"W3182978215","doi":"10.1093/noajnl/vdab070.004","title":"ECOA-4. Hypoxia alters the DNA methylation profile of glioblastoma tumor cells","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"DNA methylation; Biology; Cancer research; Angiogenesis; Tumor progression; Hypoxia (environmental); Methylation; Tumor hypoxia; CpG site; Gene; Gene expression; Genetics; Medicine; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002235142,0.0001402906,0.000191214,0.00003449781,0.0001017443,0.00001070431,0.000176341,0.0001080082,0.00005060372],"category_scores_gemma":[0.000266769,0.0001139902,0.00009748551,0.0001576746,0.0001587831,0.00000894487,0.0001052971,0.0001161031,0.00001100421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001306868,"about_ca_system_score_gemma":0.0001528075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002029681,"about_ca_topic_score_gemma":0.00006734237,"domain_scores_codex":[0.9987043,0.0002932306,0.000301964,0.0003587048,0.000134572,0.0002072997],"domain_scores_gemma":[0.9990027,0.000175943,0.0002526109,0.0003469826,0.0001721099,0.00004967469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008439017,0.00006222031,0.0004367752,0.00001737478,0.00001933653,0.000009993037,0.00004118663,0.0007614217,0.9839094,0.00006937078,0.0002572485,0.01433127],"study_design_scores_gemma":[0.0002933657,0.0005384805,0.0009256995,0.000003709421,0.00002162694,0.000009164921,0.00008752125,0.00008135624,0.8281507,0.0003484467,0.1694453,0.00009459817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989762,0.0052741,0.001095418,0.0004495019,0.000753456,0.000221732,0.00003164283,0.0000117324,0.002400381],"genre_scores_gemma":[0.995809,0.001249778,0.001977012,0.0004650152,0.0002310025,0.00003766888,0.00005006701,0.00002148911,0.0001590203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1691881,"threshold_uncertainty_score":0.4648385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009057102542455406,"score_gpt":0.2701724395996464,"score_spread":0.261115337057191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}