{"id":"W3183049553","doi":"10.3390/microorganisms9071509","title":"Predicted Cellular Interactors of the Endogenous Retrovirus-K Integrase Enzyme","year":2021,"lang":"en","type":"article","venue":"Microorganisms","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Winnipeg","funders":"Natural Sciences and Engineering Research Council of Canada; University of Winnipeg; ALS Association","keywords":"Interactome; Biology; Integrase; Retrovirus; Helicase; Computational biology; Carcinogenesis; Cell biology; Genetics; DNA; Virus; Cancer; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00007916817,0.0001852366,0.000304798,0.00006041058,0.00007673802,0.00001497903,0.000140628,0.00008870017,0.00127845],"category_scores_gemma":[0.0001191945,0.0001209944,0.000164651,0.0003727931,0.00008138312,0.00003484892,0.0001303035,0.000213168,0.00009493814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001399662,"about_ca_system_score_gemma":0.0003452532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002162479,"about_ca_topic_score_gemma":0.00001914833,"domain_scores_codex":[0.9988778,0.00006508834,0.0003277379,0.0002561594,0.0002430756,0.0002301457],"domain_scores_gemma":[0.9991151,0.00004483819,0.00009921036,0.0004819357,0.000160225,0.00009871108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003837509,0.0003389941,0.02684244,0.00004153775,0.0002658158,0.0003166827,0.002031727,1.56634e-7,0.9662455,0.00004504144,0.003343486,0.0004902611],"study_design_scores_gemma":[0.001064655,0.00005833017,0.003409781,0.0001238627,0.0002220923,0.0002464525,0.0005133086,0.000002991545,0.9802968,0.0000341929,0.0139247,0.000102823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947822,0.0005808714,0.0001398423,0.001304751,0.0003578751,0.0002797227,0.00004628099,0.00005626208,0.002452184],"genre_scores_gemma":[0.9802058,0.00003445883,0.001067801,0.0002904823,0.00006028492,0.000007022429,0.0001195967,0.00003414531,0.01818036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02343266,"threshold_uncertainty_score":0.9996345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01460466515370011,"score_gpt":0.2120877499474252,"score_spread":0.1974830847937251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}