{"id":"W3183193106","doi":"10.1139/cjpp-2021-0006","title":"The S1PR1 agonist SEW2871 promotes the survival of skin flap","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"S1PR1; Protein kinase B; Angiogenesis; Agonist; MAPK/ERK pathway; Kinase; Skin flap; Hsp27; Neovascularization; Receptor; Cell biology; Cancer research; Medicine; Pharmacology; Signal transduction; Heat shock protein; Chemistry; Biology; Vascular endothelial growth factor A; Surgery; Internal medicine; Vascular endothelial growth factor; Biochemistry; Hsp70; VEGF receptors","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007336068,0.0003722044,0.0003036831,0.0002431371,0.0001465959,0.0001495582,0.0001480799,0.0002598099,0.001755659],"category_scores_gemma":[0.00006759244,0.00009944456,0.0002384758,0.0001185971,0.0002048213,0.0002920225,0.0002184103,0.001015909,0.0003234677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001282236,"about_ca_system_score_gemma":0.000212956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003534442,"about_ca_topic_score_gemma":0.0007530255,"domain_scores_codex":[0.9999372,0.000009152475,0.000003941501,0.0000112175,0.00001600018,0.00002251883],"domain_scores_gemma":[0.9999628,0.000005118712,0.000009428454,0.000002652614,0.000005169413,0.0000148862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005233633,0.0002410178,0.0001102248,0.00008858632,0.000008115492,0.0001105312,0.00001708485,0.0001131744,0.9917859,0.00009119409,0.0001862465,0.006724411],"study_design_scores_gemma":[0.00009523741,0.002823491,0.003406307,0.00001558838,0.00002955386,0.0003038856,0.00008948467,0.001129837,0.9894781,0.0001130059,0.002507023,0.000008484265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932984,0.002735377,0.001515224,0.0002246747,0.00006931178,0.00002842099,0.0001171548,0.00006816546,0.001943331],"genre_scores_gemma":[0.9934449,0.002504204,0.001086855,0.00009657469,0.00001975432,0.00003717503,0.0001858204,0.00001274581,0.00261199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001755659,"threshold_uncertainty_score":0.005873263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009981938375335044,"score_gpt":0.2550735728891678,"score_spread":0.2450916345138328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}