{"id":"W3183228708","doi":"10.15252/embr.202052190","title":"Homologous recombination is reduced in female embryonic stem cells by two active X chromosomes","year":2021,"lang":"en","type":"article","venue":"EMBO Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Hospital Universiti Sains Malaysia; Yasuda Memorial Medical Foundation; Kanazawa University; Kindai University","keywords":"Homologous recombination; Embryonic stem cell; Biology; Homologous chromosome; Cell biology; Genetics; Recombination; Stem cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003336389,0.0006705077,0.0004734299,0.0005473502,0.0002599682,0.0009166713,0.0005832034,0.0007067429,0.005880288],"category_scores_gemma":[0.0002728735,0.0005195138,0.0004698365,0.0002170954,0.0004597853,0.0003124466,0.0006657718,0.0009818358,0.001347326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000331779,"about_ca_system_score_gemma":0.000285583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004483603,"about_ca_topic_score_gemma":0.0005323351,"domain_scores_codex":[0.9994856,0.00007474778,0.00006109149,0.0001201047,0.0001660302,0.00009245924],"domain_scores_gemma":[0.9996071,0.00007709895,0.0001304577,0.00006488402,0.00002354785,0.00009682749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007295763,0.000009955063,0.0001305165,0.00001355613,0.00000457951,0.00008458012,0.00001432955,0.00002394504,0.9987041,0.0002549915,0.00003806167,0.0006484659],"study_design_scores_gemma":[0.00002130693,0.00006499886,0.003439382,0.000003339328,0.00001305937,0.0003216807,0.00002244662,0.0003027426,0.9933211,0.00008004571,0.002405025,0.00000485439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982508,0.001291411,0.008362411,0.0003572956,0.0001178679,0.00003031107,0.0008458314,0.000449518,0.006037383],"genre_scores_gemma":[0.9834135,0.0004600903,0.001645008,0.00007902664,0.00002420152,0.0000298858,0.000772204,0.0002324699,0.01334361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005880288,"threshold_uncertainty_score":0.01967156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007324581329542383,"score_gpt":0.2793270476621564,"score_spread":0.272002466332614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}