{"id":"W3183230352","doi":"10.1016/j.stem.2021.06.004","title":"Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis","year":2021,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Occupational Cancer Research Centre; Princess Margaret Cancer Centre; University Health Network","funders":"Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation; Canadian Institutes of Health Research; Leukemia Research Foundation","keywords":"Nicotinamide phosphoribosyltransferase; Biology; Stem cell; Myeloid leukemia; Haematopoiesis; Cancer research; Apoptosis; Progenitor cell; Downregulation and upregulation; Cell biology; Sterol regulatory element-binding protein; Biochemistry; Pharmacology; NAD+ kinase; Enzyme; Cholesterol; Sterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098325,0.0003533276,0.0003358043,0.0003421427,0.0001846905,0.0003624947,0.0002514079,0.0002123878,0.001157576],"category_scores_gemma":[0.0001036596,0.0001079739,0.0002264573,0.0002504082,0.0001846805,0.0001843242,0.0001476836,0.0006030619,0.000250239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004575636,"about_ca_system_score_gemma":0.0003338821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001354128,"about_ca_topic_score_gemma":0.003097141,"domain_scores_codex":[0.9998863,0.00001469486,0.00001172804,0.00001905236,0.00003780037,0.00003048585],"domain_scores_gemma":[0.999939,0.00001437485,0.0000147418,0.000008757898,0.000008372839,0.00001482061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003444611,0.00008094423,0.0003559461,0.00002843277,0.00002049653,0.00009095893,0.0000290652,0.0001928329,0.9936373,0.0005640174,0.000124367,0.004531209],"study_design_scores_gemma":[0.00002599183,0.0002326627,0.001356514,0.000002013991,0.00002380277,0.0001161969,0.00002120088,0.0005839036,0.9954901,0.00007482131,0.002070469,0.000002165427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928716,0.001401899,0.002117094,0.0001416589,0.00004211618,0.00004830219,0.0003960895,0.0001548033,0.002826572],"genre_scores_gemma":[0.9966383,0.0005492106,0.0007323995,0.00003532056,0.00000662499,0.00002553846,0.0003003711,0.00001199348,0.001700099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354128,"threshold_uncertainty_score":0.003872514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009342197970661577,"score_gpt":0.209857265774969,"score_spread":0.2005150678043075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}