{"id":"W3183230352","doi":"10.1016/j.stem.2021.06.004","title":"Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis","year":2021,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Occupational Cancer Research Centre; Princess Margaret Cancer Centre; University Health Network","funders":"Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation; Canadian Institutes of Health Research; Leukemia Research Foundation","keywords":"Nicotinamide phosphoribosyltransferase; Biology; Stem cell; Myeloid leukemia; Haematopoiesis; Cancer research; Apoptosis; Progenitor cell; Downregulation and upregulation; Cell biology; Sterol regulatory element-binding protein; Biochemistry; Pharmacology; NAD+ kinase; Enzyme; Cholesterol; Sterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00028581,0.0003883871,0.0004173574,0.00005233947,0.0001508166,0.00005179866,0.0003027028,0.0003495273,0.00007031699],"category_scores_gemma":[0.000007213368,0.0004166871,0.0002737191,0.0003664681,0.00008213252,0.00001064902,0.0001739254,0.0002734952,0.00003442149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004917132,"about_ca_system_score_gemma":0.0002126114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000423943,"about_ca_topic_score_gemma":0.000008319003,"domain_scores_codex":[0.9975747,0.000232242,0.0005549925,0.0007886117,0.0002853815,0.0005640391],"domain_scores_gemma":[0.9987036,0.00005897777,0.0002396163,0.000525872,0.0002421929,0.0002297644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006572478,0.0003293474,0.0007339407,0.0003486786,0.0000440618,0.00000488424,0.0003412599,0.00002218008,0.9874607,0.000004762898,0.003212078,0.007432346],"study_design_scores_gemma":[0.0008110025,0.0003453115,0.00001720193,0.00005254179,0.00005583479,0.000004731215,0.001131902,0.00001175427,0.9736661,0.000002998573,0.02344748,0.0004531695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879287,0.005514229,0.0005157743,0.00003667334,0.0003874135,0.000353495,0.0003162663,0.00003155594,0.004915843],"genre_scores_gemma":[0.9945373,0.001107558,0.0003022322,0.0001152481,0.0001934627,0.00003910699,0.0001636101,0.00007991894,0.003461565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0202354,"threshold_uncertainty_score":0.9998285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009342197970661577,"score_gpt":0.209857265774969,"score_spread":0.2005150678043075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}