{"id":"W3183254943","doi":"10.1038/s41586-021-03752-4","title":"Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":547,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute; Ludwig Center at Harvard; Sidney Kimmel Comprehensive Cancer Center; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; National Institutes of Health; Promotion and Mutual Aid Corporation for Private Schools of Japan; Swim Across America; Mark Foundation For Cancer Research; Parker Institute for Cancer Immunotherapy; Johns Hopkins University; Memorial Sloan-Kettering Cancer Center; Stand Up To Cancer; LUNGevity Foundation; Entertainment Industry Foundation; Commonwealth Foundation; Lustgarten Foundation; International Association for the Study of Lung Cancer; American Society of Clinical Oncology; American Association for Cancer Research; Bristol-Myers Squibb; Allegheny Health Network; Virginia and D.K. Ludwig Fund for Cancer Research; Damon Runyon Cancer Research Foundation; Bloomberg Philanthropies; Conquer Cancer Foundation; Cancer Research Institute; V Foundation for Cancer Research","keywords":"Cancer research; Lung; PD-L1; Biology; Medicine; Genetics; Internal medicine; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007941027,0.0001000825,0.0001993273,0.0002150728,0.00008741434,0.0001954124,0.00008726335,0.0001589913,0.001386517],"category_scores_gemma":[0.0001177198,0.00008676251,0.0001684538,0.0001296418,0.0001244408,0.0001064485,0.0001073847,0.000384855,0.0003520657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002322318,"about_ca_system_score_gemma":0.0001150035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003383266,"about_ca_topic_score_gemma":0.0004046579,"domain_scores_codex":[0.9998739,0.00001390668,0.000009135206,0.0000362641,0.0000330077,0.00003379451],"domain_scores_gemma":[0.9998938,0.00002296137,0.00002285367,0.000009906465,0.00002334935,0.00002702872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001743438,0.00002856616,0.001030194,0.00001818407,0.000002451115,0.00002012716,0.00002979752,0.00009763224,0.9972267,0.00003088603,0.00003819271,0.001302887],"study_design_scores_gemma":[0.00001857748,0.0008647034,0.03266969,0.000004892902,0.00001584715,0.0001692381,0.0001496281,0.002601135,0.9617035,0.00006893813,0.001728925,0.000004936011],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975778,0.0004107694,0.0007972694,0.000026739,0.00001381068,0.0000197836,0.0004580399,0.00004270798,0.000653077],"genre_scores_gemma":[0.9967617,0.0001472566,0.0007887015,0.00004387677,0.000005662667,0.00004783422,0.0006970083,0.00001460685,0.001493285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001386517,"threshold_uncertainty_score":0.004638374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01341387448868842,"score_gpt":0.2767093766894635,"score_spread":0.2632955022007751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}