{"id":"W3183257671","doi":"10.1093/abt/tbab015","title":"SARS-CoV-2 receptor-binding mutations and antibody contact sites","year":2021,"lang":"en","type":"article","venue":"Antibody Therapeutics","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Toronto","keywords":"Antibody; Point mutation; Mutation; Immune escape; Infectivity; Biology; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Neutralization; Receptor; Binding site; Genetics; Coronavirus disease 2019 (COVID-19); Virus; Gene; Immune system; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003056303,0.0003758717,0.0004416203,0.001060392,0.0002791297,0.0004345458,0.0002564975,0.0003051292,0.003037269],"category_scores_gemma":[0.0008779148,0.0001098925,0.000695962,0.001359921,0.0001412368,0.0002731807,0.0002746845,0.0003063301,0.001093864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002491365,"about_ca_system_score_gemma":0.0003870322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003792654,"about_ca_topic_score_gemma":0.00770333,"domain_scores_codex":[0.9996035,0.00004536479,0.00003922862,0.0001432472,0.0001036401,0.0000651191],"domain_scores_gemma":[0.9996585,0.0001019658,0.0001246346,0.00003710568,0.0000451622,0.00003264998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0018161,0.0003467005,0.789503,0.001175379,0.0006328875,0.001809983,0.0002015036,0.01995527,0.08908763,0.00114838,0.02400316,0.07031992],"study_design_scores_gemma":[0.00009599994,0.0004706829,0.8710971,0.0001248741,0.0003743052,0.004152081,0.0003474513,0.04188738,0.02593377,0.001579931,0.05387508,0.0000612427],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9429629,0.001839982,0.002282971,0.00016145,0.00003958496,0.00004370013,0.04942939,0.000446324,0.002793714],"genre_scores_gemma":[0.8960956,0.0006673631,0.004683356,0.0001483906,0.00002179298,0.00005148145,0.09709841,0.00008077532,0.00115283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003792654,"threshold_uncertainty_score":0.01016068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07671401143112645,"score_gpt":0.4119367174553563,"score_spread":0.3352227060242299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}