{"id":"W3183292683","doi":"10.1371/journal.pone.0254149","title":"Activation and gut-homing of peripheral T cells in HIV immunologic non-responders despite long term viral suppression","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Maple Leaf Medical Clinic; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"CD8; Immunology; Medicine; Immune system; Context (archaeology); Viral load; Internal medicine; Biomarker; Cytotoxic T cell; Biology; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006427115,0.0002109838,0.0002687574,0.0003279843,0.0002366682,0.0004258854,0.0001690554,0.0002225995,0.001486191],"category_scores_gemma":[0.00128595,0.0001616342,0.000182095,0.0002008603,0.0001381812,0.0002035496,0.0002235101,0.0002768016,0.0002242378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009563362,"about_ca_system_score_gemma":0.00009112073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004903327,"about_ca_topic_score_gemma":0.0005390692,"domain_scores_codex":[0.9997255,0.0001089445,0.00002630982,0.00006491801,0.00003344122,0.00004072128],"domain_scores_gemma":[0.9993067,0.000118675,0.0003378915,0.0000693669,0.00005971048,0.0001077467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001576715,0.0001158407,0.9909019,0.00002656061,0.00004051003,0.0001822041,0.0001205064,0.0000394828,0.004216214,0.00001704632,0.00005419476,0.0027088],"study_design_scores_gemma":[0.00002892791,0.001069476,0.9971496,0.000008612487,0.00003117757,0.0006898429,0.0001885525,0.0001641227,0.000508789,0.00002169126,0.0001363163,0.000002818433],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997498,0.00006121812,0.00003609307,0.000004911942,0.000001374379,0.00000498459,0.00005264538,0.000001240757,0.00008765052],"genre_scores_gemma":[0.9997479,0.00001751986,0.00004656838,0.000007908531,0.000002683812,0.000004811813,0.00007320612,7.230316e-7,0.00009853779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001486191,"threshold_uncertainty_score":0.004971802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02585411706230314,"score_gpt":0.2473592217228245,"score_spread":0.2215051046605214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}