{"id":"W3183300604","doi":"10.1016/s2213-8587(21)00180-7","title":"Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":245,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Novo Nordisk; Bayer Fund; Novartis; Servier; Amgen; Pfizer; Bristol-Myers Squibb; AstraZeneca; Fundação Lemann; Boehringer Ingelheim","keywords":"Medicine; Dapagliflozin; Discontinuation; Placebo; Internal medicine; Adverse effect; Hazard ratio; Population; Kidney disease; Organ dysfunction; Randomized controlled trial; Clinical trial; Diabetes mellitus; Type 2 diabetes; Confidence interval; Sepsis; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001438843,0.001676213,0.00339256,0.0003669488,0.0003378473,0.001256351,0.0007854088,0.001874303,0.006090382],"category_scores_gemma":[0.001498396,0.0006248078,0.002399023,0.0004109263,0.0009369981,0.001175282,0.0004597163,0.003872016,0.0009648789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006116588,"about_ca_system_score_gemma":0.0006721049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009332088,"about_ca_topic_score_gemma":0.002076779,"domain_scores_codex":[0.9996086,0.000161144,0.00003034038,0.00007699648,0.00003346379,0.00008944688],"domain_scores_gemma":[0.9994523,0.0001629986,0.0001125032,0.00003739209,0.00002975553,0.0002050128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.979908,0.002087106,0.0005749647,0.0009414057,0.001268493,0.00004357954,0.00003156902,0.0001692231,0.001306486,0.0001199661,0.001200913,0.01234836],"study_design_scores_gemma":[0.9873882,0.01065915,0.0009967136,0.00002956235,0.0003051922,0.00001654101,0.00001030749,0.0001324249,0.00008085176,0.00006764114,0.0003060549,0.000007289063],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9619607,0.02217036,0.001400017,0.002140598,0.002060638,0.003063274,0.002315168,0.0003614444,0.004527786],"genre_scores_gemma":[0.9722177,0.01049343,0.002235132,0.00391137,0.001219162,0.003009252,0.002664857,0.00004545164,0.004203754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006090382,"threshold_uncertainty_score":0.0203743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03020509431940633,"score_gpt":0.3003468337290783,"score_spread":0.270141739409672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}