{"id":"W3183309084","doi":"10.1016/j.mce.2021.111401","title":"Nucleobindin-derived nesfatin-1 and nesfatin-1-like peptide stimulate pro-opiomelanocortin synthesis in murine AtT-20 corticotrophs through the cAMP/PKA/CREB signaling pathway","year":2021,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Ferring Pharmaceuticals","keywords":"Corticotropic cell; CREB; Proopiomelanocortin; Biology; Internal medicine; Endocrinology; Forskolin; Protein kinase A; Molecular biology; Cell biology; Anterior pituitary; Phosphorylation; Hypothalamus; Stimulation; Gene; Biochemistry; Transcription factor; Medicine; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001778755,0.0005104537,0.0002985937,0.0005192677,0.0002190894,0.0003867993,0.0002445129,0.0003261654,0.001542353],"category_scores_gemma":[0.0001993458,0.0002770931,0.0004018115,0.0001552342,0.0004477262,0.0003335378,0.0003835529,0.0008737277,0.0004573545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007023675,"about_ca_system_score_gemma":0.0003346883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001486726,"about_ca_topic_score_gemma":0.0039873,"domain_scores_codex":[0.9998062,0.00002502232,0.0000140855,0.00003500457,0.00005338139,0.00006628423],"domain_scores_gemma":[0.9997227,0.00005905888,0.00004922888,0.00002134181,0.0000211858,0.0001265438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003233587,0.00001961703,0.00008053526,0.00001439717,0.000002680042,0.00005251321,0.00001269841,0.00002413278,0.9990884,0.0000659076,0.00002036835,0.0002953126],"study_design_scores_gemma":[0.00005868692,0.000358222,0.007127361,0.000009027611,0.00001393652,0.0002341476,0.00006826597,0.0006318148,0.9889891,0.0001317806,0.002367296,0.00001034154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921141,0.002587148,0.00160382,0.0002467002,0.00008022675,0.00002711362,0.0006059349,0.00006731968,0.00266785],"genre_scores_gemma":[0.9878767,0.001079396,0.002699445,0.0001814406,0.00004530512,0.0000642038,0.001578491,0.00006833234,0.006406775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001542353,"threshold_uncertainty_score":0.005159736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0188831249421533,"score_gpt":0.2360972063291778,"score_spread":0.2172140813870245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}