{"id":"W3183326570","doi":"10.1128/mbio.01115-21","title":"Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Canada Research Chairs; Government of Canada","keywords":"Type VI secretion system; Recombinase; Effector; Vibrio cholerae; Biology; Secretion; Synthetic biology; Computational biology; Pseudomonas aeruginosa; Chaperone (clinical); Cell biology; Gene; Genetics; Bacteria; Virulence; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004543099,0.0005331008,0.0002908749,0.0003793109,0.0001499196,0.0007294762,0.000411631,0.0007402784,0.001228924],"category_scores_gemma":[0.000434259,0.0002663966,0.000410399,0.0002626307,0.0003318969,0.0004511154,0.0004576471,0.0009239549,0.001195313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003860774,"about_ca_system_score_gemma":0.0002811009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002955637,"about_ca_topic_score_gemma":0.0003504094,"domain_scores_codex":[0.9995918,0.00007892081,0.00005376166,0.00005816382,0.0001677037,0.0000497584],"domain_scores_gemma":[0.9996025,0.000059933,0.0001887687,0.00005926267,0.00004199492,0.00004759333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002854691,0.00001884612,0.0001178859,0.00004397453,0.000005319505,0.00003793916,0.00001510424,0.00008280188,0.9975203,0.0003535671,0.00005476358,0.001720871],"study_design_scores_gemma":[0.000009151257,0.00009035016,0.0002531698,0.000005943484,0.000006922443,0.0001831379,0.00001086711,0.0004189762,0.9940947,0.00006110862,0.004860361,0.000005483305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7968199,0.003942626,0.1867614,0.0007129576,0.0004190285,0.0004229199,0.001562398,0.001403897,0.007954865],"genre_scores_gemma":[0.905201,0.002685265,0.07568809,0.0002383561,0.00004213668,0.000113044,0.001868633,0.0003230788,0.01384043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001228924,"threshold_uncertainty_score":0.004111171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009878195996470452,"score_gpt":0.2399424281629437,"score_spread":0.2300642321664733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}