{"id":"W3183326570","doi":"10.1128/mbio.01115-21","title":"Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Canada Research Chairs; Government of Canada","keywords":"Type VI secretion system; Recombinase; Effector; Vibrio cholerae; Biology; Secretion; Synthetic biology; Computational biology; Pseudomonas aeruginosa; Chaperone (clinical); Cell biology; Gene; Genetics; Bacteria; Virulence; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007281858,0.0001034664,0.0001199929,0.00002051731,0.00006964303,0.00003252964,0.00004962219,0.0000944873,0.00001849482],"category_scores_gemma":[0.0001803042,0.00009871209,0.0000310674,0.00007282691,0.00003715596,0.00000316298,0.0001237041,0.00006284788,0.0000132769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000023795,"about_ca_system_score_gemma":0.00004261114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005384745,"about_ca_topic_score_gemma":0.00003382522,"domain_scores_codex":[0.9993326,0.00008811314,0.00007943417,0.0002426861,0.00007717058,0.0001799703],"domain_scores_gemma":[0.9995539,0.000017454,0.0000231051,0.0001809705,0.0001573931,0.00006714377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007756335,0.00002999597,0.0008350307,0.00006387826,0.0001156646,0.00002894205,0.00007503082,0.000007643692,0.9967436,0.00001478214,0.0009535413,0.001054396],"study_design_scores_gemma":[0.0009816446,0.0006876798,0.03093237,0.00005079079,0.00003853003,0.0000704879,0.0003580878,0.0001375383,0.9377715,0.00001068227,0.02865755,0.0003031274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963946,0.002745801,0.00005577379,0.000050981,0.0002727683,0.0001540811,0.00002930848,0.00001250496,0.0002841606],"genre_scores_gemma":[0.9980884,0.0007315333,0.00005625774,0.00002300826,0.000115245,0.00001761085,0.0002214746,0.00001474557,0.0007317796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05897202,"threshold_uncertainty_score":0.4025362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009878195996470452,"score_gpt":0.2399424281629437,"score_spread":0.2300642321664733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}