{"id":"W3183327814","doi":"10.1039/d1md00206f","title":"A niclosamide–tobramycin hybrid adjuvant potentiates cefiderocol against<i>P. aeruginosa</i>","year":2021,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Institute of Infection and Immunity; Natural Sciences and Engineering Research Council of Canada; University of Manitoba","keywords":"Niclosamide; Tobramycin; Adjuvant; Antibiotics; Antimicrobial; Microbiology; Siderophore; Biology; Pharmacology; Chemistry; Bacteria; Immunology; Gentamicin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002072353,0.0003616626,0.00039465,0.00001778761,0.0001231583,0.00005045602,0.0003814056,0.0002319776,0.0003825054],"category_scores_gemma":[0.0004278917,0.0003567599,0.0002031482,0.0001341766,0.0002161063,0.00000781115,0.0002439462,0.0002821025,0.00004409125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004882703,"about_ca_system_score_gemma":0.0003932457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008987941,"about_ca_topic_score_gemma":0.000006356202,"domain_scores_codex":[0.9976913,0.00005910389,0.0004819664,0.0007981581,0.0004028694,0.0005666187],"domain_scores_gemma":[0.9984338,0.0000313887,0.0001868973,0.0008388507,0.000222338,0.0002867157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000868819,0.00009753244,0.004711987,0.0002128715,0.00009985346,0.0004174999,0.00001616856,0.000009679346,0.9794219,0.000008413136,0.01327179,0.001645415],"study_design_scores_gemma":[0.0009039803,0.00004917313,0.002228943,0.000182692,0.00006007759,0.0004051668,0.0002972707,0.00003706946,0.9615338,0.00008196959,0.03382054,0.000399323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982721,0.004513097,0.0007103543,0.0005311063,0.0002759996,0.0001708512,0.00005260434,0.00004851485,0.01097649],"genre_scores_gemma":[0.9909169,0.0008530301,0.0009050384,0.001214049,0.0009514474,0.00001997886,0.0008608282,0.00005552616,0.004223214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02054875,"threshold_uncertainty_score":0.9998884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006388304404746333,"score_gpt":0.2295534417550029,"score_spread":0.2231651373502566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}