{"id":"W3183351508","doi":"10.3390/cells10081884","title":"Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Alzheimer's Society; Research Manitoba","keywords":"Oxidative stress; Synaptic plasticity; Neuroscience; Reactive oxygen species; Transcription factor; Reactive nitrogen species; KEAP1; Neurodegeneration; Biology; Chemistry; Cell biology; Disease; Medicine; Internal medicine; Biochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005962171,0.0009338226,0.001222831,0.001870129,0.0003220454,0.0008574635,0.0009622153,0.001213997,0.003523705],"category_scores_gemma":[0.0005274387,0.0002664385,0.0003952301,0.001945922,0.0004631478,0.001289116,0.0008028452,0.001928962,0.002525852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006886058,"about_ca_system_score_gemma":0.0009362293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008967667,"about_ca_topic_score_gemma":0.00217473,"domain_scores_codex":[0.9998833,0.00002297609,0.00001865171,0.00002174422,0.00003907787,0.00001429081],"domain_scores_gemma":[0.9998009,0.00007217809,0.00002731302,0.000006155714,0.00006418501,0.00002923772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001183917,0.00006988273,0.0001298445,0.01652164,0.00009246707,0.0002872108,0.00006349014,0.0003401851,0.001900372,0.004779557,0.04308281,0.9326141],"study_design_scores_gemma":[0.00002211799,0.0000802278,0.0005720571,0.002769068,0.00008105592,0.001086398,0.00004023706,0.00006519955,0.0003550949,0.002319042,0.9925944,0.00001508258],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007308021,0.998632,0.00007765924,0.000270149,0.0002357789,0.00000359772,0.00001364098,0.000005644016,0.0006883902],"genre_scores_gemma":[0.0004525341,0.9986081,0.00009905305,0.0001704508,0.0001371077,0.000005143459,0.00002414355,0.000001033877,0.0005024762],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003523705,"threshold_uncertainty_score":0.01178795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0208083368415503,"score_gpt":0.2796939062131374,"score_spread":0.2588855693715871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}