{"id":"W3183386301","doi":"10.1038/s41392-021-00704-2","title":"N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding","year":2021,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute","funders":"Beijing Municipal Administration of Hospitals","keywords":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Virology; Mutation; Transmission (telecommunications); Sars virus; Receptor; Betacoronavirus; Biology; Molecular biology; Medicine; Genetics; Pathology; Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008724474,0.000683072,0.000625016,0.0002473482,0.0009947252,0.0008119228,0.0005731234,0.01315399,0.002445641],"category_scores_gemma":[0.002221356,0.0003207634,0.0007934602,0.0001254523,0.000914985,0.0005052887,0.0003320207,0.005131762,0.00140059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001172244,"about_ca_system_score_gemma":0.000680636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00241281,"about_ca_topic_score_gemma":0.003910995,"domain_scores_codex":[0.9994825,0.0001247039,0.0000563157,0.00006879956,0.0001410483,0.0001265179],"domain_scores_gemma":[0.9992722,0.0004558746,0.00007046275,0.00003451508,0.00007347413,0.00009338841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002374456,0.0009224747,0.008960282,0.0002750057,0.000251059,0.1655464,0.0005561884,0.001177197,0.07610998,0.01768003,0.6724268,0.05372007],"study_design_scores_gemma":[0.001459604,0.003441948,0.02352894,0.0003944776,0.0003190051,0.1036971,0.0008358644,0.01054035,0.05225913,0.01652779,0.7867306,0.0002651009],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1520544,0.003638922,0.003823898,0.7304295,0.03094786,0.0002961584,0.0007619818,0.0006748397,0.07737254],"genre_scores_gemma":[0.4581544,0.004289981,0.004028826,0.4320371,0.02062963,0.0002070017,0.000411242,0.0001800582,0.08006179],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01315399,"threshold_uncertainty_score":0.008505285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05250129707126622,"score_gpt":0.3420590178349025,"score_spread":0.2895577207636363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}