{"id":"W3183408771","doi":"10.1097/wno.0000000000001316","title":"Cross-Sectional Analysis of Baseline Visual Parameters in Subjects Recruited Into the RESCUE and REVERSE ND4-LHON Gene Therapy Studies","year":2021,"lang":"en","type":"article","venue":"Journal of Neuro-Ophthalmology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Medical Research Council; Isaac Newton Trust; National Institutes of Health; Ministero della Salute; E-Rare; Agence Nationale de la Recherche; National Eye Institute; Moorfields Eye Charity; Sight Research UK; Moorfields Eye Hospital NHS Foundation Trust; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research","keywords":"Medicine; Ophthalmology; Visual acuity; Nerve fiber layer; Optical coherence tomography; Retinal; Visual field; Cross-sectional study; Clinical trial; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001288055,0.0002703049,0.000437569,0.0004874657,0.0003456741,0.0003315311,0.0001211689,0.000359206,0.001104174],"category_scores_gemma":[0.001542571,0.0001810359,0.0002928684,0.0002781837,0.0002090718,0.0003193521,0.0002714614,0.000323879,0.0002626845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001697848,"about_ca_system_score_gemma":0.0001814681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026127,"about_ca_topic_score_gemma":0.001076416,"domain_scores_codex":[0.9993813,0.0002134532,0.0000595088,0.0001777998,0.00009654268,0.00007138386],"domain_scores_gemma":[0.9987305,0.0002512527,0.0004724746,0.0001129301,0.0002274818,0.000205402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002717097,0.0003862645,0.9901937,0.00001971737,0.0001362203,0.0001363469,0.0001543343,0.00003520093,0.002924185,0.00001338546,0.0001083098,0.0031753],"study_design_scores_gemma":[0.00005174078,0.002093272,0.9970892,0.000002671442,0.00003862848,0.0002152973,0.0000923128,0.00005764449,0.0001721559,0.000006382644,0.0001775176,0.000003147857],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991614,0.0002040117,0.0001143478,0.000009169724,0.000003165552,0.00004678385,0.0002035039,0.00000324242,0.0002542603],"genre_scores_gemma":[0.9990802,0.00004354567,0.0001310892,0.00003767518,0.000007811158,0.00005828415,0.0004563149,0.000001793103,0.0001833486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001288055,"threshold_uncertainty_score":0.006811976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0481988938342225,"score_gpt":0.361278599873893,"score_spread":0.3130797060396706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}