{"id":"W3183408771","doi":"10.1097/wno.0000000000001316","title":"Cross-Sectional Analysis of Baseline Visual Parameters in Subjects Recruited Into the RESCUE and REVERSE ND4-LHON Gene Therapy Studies","year":2021,"lang":"en","type":"article","venue":"Journal of Neuro-Ophthalmology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Medical Research Council; Isaac Newton Trust; National Institutes of Health; Ministero della Salute; E-Rare; Agence Nationale de la Recherche; National Eye Institute; Moorfields Eye Charity; Sight Research UK; Moorfields Eye Hospital NHS Foundation Trust; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research","keywords":"Medicine; Ophthalmology; Visual acuity; Nerve fiber layer; Optical coherence tomography; Retinal; Visual field; Cross-sectional study; Clinical trial; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007383905,0.0001370258,0.0003663102,0.0002384604,0.00005900592,0.00001621549,0.0001350169,0.000117269,0.00002583192],"category_scores_gemma":[0.0009630313,0.00009978349,0.0001900514,0.0005124669,0.0002048638,0.000008428913,0.00009170925,0.0001748829,3.158296e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001460419,"about_ca_system_score_gemma":0.000116358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003004772,"about_ca_topic_score_gemma":0.00002660499,"domain_scores_codex":[0.9984087,0.0004453965,0.0005672303,0.0002451459,0.0001723824,0.0001611528],"domain_scores_gemma":[0.9989127,0.000230199,0.0002872591,0.0001551829,0.0003675504,0.00004708773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009410034,0.0001152586,0.6325822,0.00001157431,0.0008452412,0.0004522133,0.0002574511,0.001108586,0.3632571,0.000002543989,0.00008460013,0.0003422278],"study_design_scores_gemma":[0.001172507,0.0008668634,0.9020683,0.00001144835,0.0001099001,0.001807343,0.0003900572,0.0001139419,0.09273714,0.0001211316,0.0004640951,0.0001372809],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941341,0.005047605,0.00002187978,0.0004655659,0.0002305433,0.00006671862,0.000002971334,0.000001061537,0.0000295743],"genre_scores_gemma":[0.9948683,0.004103858,0.0005125314,0.0003103734,0.00005385066,0.000003548093,0.00002288033,0.000009901692,0.0001147666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.27052,"threshold_uncertainty_score":0.4069053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0481988938342225,"score_gpt":0.361278599873893,"score_spread":0.3130797060396706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}