{"id":"W3183465146","doi":"10.1186/s12885-021-08579-w","title":"Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation","year":2021,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fondation ARC pour la Recherche sur le Cancer; Institut Gustave-Roussy; Fondation Philanthropia","keywords":"Cancer research; Panobinostat; EGFR inhibitors; Histone deacetylase inhibitor; Histone deacetylase; Epithelioid sarcoma; Downregulation and upregulation; Growth factor receptor; Epidermal growth factor receptor; Biology; Medicine; Sarcoma; Pathology; Receptor; Internal medicine; Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008104976,0.0002976175,0.0003140826,0.0001887773,0.00007504826,0.0001215975,0.0001368587,0.0001193123,0.001324771],"category_scores_gemma":[0.00005628272,0.00009828564,0.0002096361,0.0001497881,0.0001064249,0.0000873441,0.00008836837,0.0003504822,0.0002184405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002077571,"about_ca_system_score_gemma":0.0001958457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000656727,"about_ca_topic_score_gemma":0.00252829,"domain_scores_codex":[0.9999312,0.000008073995,0.000006923219,0.00001605912,0.00001929119,0.00001844687],"domain_scores_gemma":[0.9999691,0.000003803344,0.000008890867,0.000003956251,0.000005737529,0.000008425559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003609406,0.00009406055,0.0004415516,0.00009637711,0.00001924504,0.00004116665,0.00001011833,0.0001764111,0.9926999,0.0000444656,0.0001253635,0.005890415],"study_design_scores_gemma":[0.00009609386,0.001780535,0.008732117,0.000008862477,0.00006097505,0.0003194478,0.00002421609,0.0009264165,0.9841079,0.00003186865,0.003906492,0.000005160271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915176,0.004448819,0.0009898396,0.00006628082,0.00003544422,0.00004991014,0.0004760403,0.00009635922,0.00231969],"genre_scores_gemma":[0.9949709,0.001888739,0.0008937507,0.00004238347,0.000006540488,0.0000319808,0.0007956005,0.00000940162,0.001360688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001324771,"threshold_uncertainty_score":0.004431784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01345370122118422,"score_gpt":0.2723785671090741,"score_spread":0.2589248658878899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}