{"id":"W3183483136","doi":"10.1016/j.clcc.2021.07.004","title":"Phase II Trial of Trametinib and Panitumumab in RAS/RAF Wild Type Metastatic Colorectal Cancer","year":2021,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Cancer Society Research Institute; Bristol-Myers Squibb Canada; Genentech; Servier; Canadian Cancer Society; Astellas Pharma Canada; Roche; Novartis; National Cancer Institute; Johnson and Johnson; AbbVie; Sanofi; GlaxoSmithKline; Merck; Bayer; American Society of Clinical Oncology; AstraZeneca; Pfizer; Conquer Cancer Foundation","keywords":"Panitumumab; Medicine; Colorectal cancer; Trametinib; Oncology; Internal medicine; Cancer research; Cancer; KRAS; MAPK/ERK pathway; Kinase; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001842957,0.00124381,0.001519687,0.0003345196,0.0003292274,0.0007384187,0.0006395055,0.0009635919,0.003221616],"category_scores_gemma":[0.0006667328,0.0005536798,0.0009642802,0.0003318644,0.0006026989,0.0005797042,0.0002963739,0.002655701,0.0006423478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008858652,"about_ca_system_score_gemma":0.00141291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008518439,"about_ca_topic_score_gemma":0.002957215,"domain_scores_codex":[0.9996538,0.0001589088,0.00002257261,0.0000596149,0.00003332828,0.00007176023],"domain_scores_gemma":[0.9995112,0.00007523395,0.0001006928,0.00004145694,0.00003112761,0.0002403206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8282796,0.0453546,0.007406834,0.0008189111,0.001248269,0.0002429198,0.0002467184,0.002914539,0.03720543,0.0002520768,0.00307471,0.0729555],"study_design_scores_gemma":[0.6480756,0.3342786,0.009176247,0.00003250206,0.0003511484,0.0003187458,0.00003654095,0.001527537,0.004233355,0.0001235294,0.001825993,0.00002013362],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943228,0.001401806,0.0003257312,0.0003186648,0.00009605455,0.001864118,0.0006031991,0.00005870185,0.0010089],"genre_scores_gemma":[0.990541,0.0009828666,0.001346724,0.0004155049,0.0001175361,0.002397401,0.001847725,0.00001767524,0.002333541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003221616,"threshold_uncertainty_score":0.01077735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09049597588417536,"score_gpt":0.4414220542320842,"score_spread":0.3509260783479089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}