{"id":"W3183483136","doi":"10.1016/j.clcc.2021.07.004","title":"Phase II Trial of Trametinib and Panitumumab in RAS/RAF Wild Type Metastatic Colorectal Cancer","year":2021,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Cancer Society Research Institute; Bristol-Myers Squibb Canada; Genentech; Servier; Canadian Cancer Society; Astellas Pharma Canada; Roche; Novartis; National Cancer Institute; Johnson and Johnson; AbbVie; Sanofi; GlaxoSmithKline; Merck; Bayer; American Society of Clinical Oncology; AstraZeneca; Pfizer; Conquer Cancer Foundation","keywords":"Panitumumab; Medicine; Colorectal cancer; Trametinib; Oncology; Internal medicine; Cancer research; Cancer; KRAS; MAPK/ERK pathway; Kinase; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005301407,0.0003598193,0.001585939,0.0001138276,0.0001327352,0.00002041229,0.0001040313,0.0001994607,0.0008924329],"category_scores_gemma":[0.00117468,0.0002943758,0.0003217215,0.0007727534,0.0005095979,0.00009162467,0.000191269,0.0005378591,0.000004571592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002721881,"about_ca_system_score_gemma":0.001271433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006243847,"about_ca_topic_score_gemma":0.004634698,"domain_scores_codex":[0.9969215,0.0002435274,0.001195323,0.0007563635,0.0004114999,0.0004717514],"domain_scores_gemma":[0.9980749,0.0007219478,0.0003038319,0.000215131,0.0004126257,0.0002715879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4647367,0.022165,0.08224302,0.0005764873,0.002613725,0.0008525635,0.001963507,0.00001593687,0.009080573,0.0001801848,0.002953613,0.4126187],"study_design_scores_gemma":[0.597371,0.1227625,0.2235843,0.001014414,0.003688056,0.0001133662,0.001452464,0.0006218327,0.02490668,0.0005286369,0.02268753,0.001269159],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820626,0.01202424,0.000001501446,0.001438657,0.00156685,0.00126158,0.0001680849,0.00004226845,0.001434228],"genre_scores_gemma":[0.9906324,0.007236607,0.0002431119,0.0004045287,0.0004042699,0.000500426,0.00003683456,0.00004282104,0.0004990432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4113495,"threshold_uncertainty_score":0.9999508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09049597588417536,"score_gpt":0.4414220542320842,"score_spread":0.3509260783479089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}