{"id":"W3183589935","doi":"10.1002/chem.202102062","title":"Cover Feature: Design, Synthesis, and Biochemical Evaluation of Alpha‐Amanitin Derivatives Containing Analogs of the <i>trans</i>‐Hydroxyproline Residue for Potential Use in Antibody‐Drug Conjugates (Chem. Eur. J. 40/2021)","year":2021,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Residue (chemistry); Conjugate; Chemistry; Drug; Stereochemistry; Hydroxyproline; Antibody; Warhead; Biochemistry; Combinatorial chemistry; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00183854,0.0002068816,0.0003805338,0.00003909284,0.0001636472,0.00004263766,0.0002532514,0.0001138277,0.000263292],"category_scores_gemma":[0.001171276,0.0001716273,0.0001593771,0.0001364581,0.0002899854,0.000114854,0.0001020393,0.0004829234,0.000001366608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003077734,"about_ca_system_score_gemma":0.0002149864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004090641,"about_ca_topic_score_gemma":9.658365e-7,"domain_scores_codex":[0.997775,0.0009902291,0.000558215,0.0002904103,0.0001145074,0.0002716143],"domain_scores_gemma":[0.9985313,0.0003325722,0.0004329564,0.0002501183,0.0004205559,0.00003246537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004889879,0.0001277459,0.0003217318,0.0000740896,0.0001764051,0.00001690394,0.000325794,0.00006617839,0.997212,0.000006249178,0.0005806444,0.0006032809],"study_design_scores_gemma":[0.002954516,0.00006152706,0.005933268,0.0004617557,0.0002174076,0.0004199538,0.0004027244,0.0002957641,0.9884908,0.00006696724,0.0005250977,0.0001702235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912717,0.005093045,0.002804889,0.0002661304,0.0001299493,0.0002315313,0.000100645,0.000006568397,0.00009551357],"genre_scores_gemma":[0.9980303,0.0004802275,0.0009991925,0.00005590224,0.00006017919,0.000006346841,0.00006976283,0.00003032789,0.000267785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008721193,"threshold_uncertainty_score":0.6998758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02252304108987788,"score_gpt":0.24860878013425,"score_spread":0.2260857390443721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}