{"id":"W3183589935","doi":"10.1002/chem.202102062","title":"Cover Feature: Design, Synthesis, and Biochemical Evaluation of Alpha‐Amanitin Derivatives Containing Analogs of the <i>trans</i>‐Hydroxyproline Residue for Potential Use in Antibody‐Drug Conjugates (Chem. Eur. J. 40/2021)","year":2021,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Residue (chemistry); Conjugate; Chemistry; Drug; Stereochemistry; Hydroxyproline; Antibody; Warhead; Biochemistry; Combinatorial chemistry; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008900103,0.0003883544,0.0002146569,0.0001431942,0.000132554,0.0001594798,0.0003688144,0.0005076603,0.01582178],"category_scores_gemma":[0.00009234748,0.0001121997,0.0001937777,0.0001695253,0.0001033519,0.0002483309,0.0001556665,0.0002757157,0.005484266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002397518,"about_ca_system_score_gemma":0.00009855452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002210017,"about_ca_topic_score_gemma":0.0003656928,"domain_scores_codex":[0.9999517,0.000003467868,0.000002261652,0.000009673481,0.00002297911,0.000009840663],"domain_scores_gemma":[0.9999554,0.000006884231,0.00001082717,0.000003168853,0.000006566155,0.00001714795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004158837,0.0002724267,0.0001575138,0.0002677408,0.00001076719,0.0002852014,0.00001651766,0.0006999363,0.9113961,0.0007683526,0.01710514,0.06860439],"study_design_scores_gemma":[0.0002804495,0.006011355,0.004034145,0.00004805755,0.00003019915,0.0009483059,0.00001951614,0.001842312,0.8421312,0.0004765844,0.1441546,0.00002315511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6086016,0.04812298,0.0282617,0.00545422,0.004914775,0.002226949,0.006551065,0.002322432,0.2935443],"genre_scores_gemma":[0.7713732,0.01968969,0.01921876,0.002098377,0.00113068,0.0006110847,0.005726476,0.0003139975,0.1798378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01582178,"threshold_uncertainty_score":0.05292916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02252304108987788,"score_gpt":0.24860878013425,"score_spread":0.2260857390443721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}