{"id":"W3183659755","doi":"10.1101/2021.07.26.453858","title":"Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"GNAQ; Melanoma; Cancer research; Melanocyte; Oncogene; Biology; Crosstalk; Signal transduction; Epidermis (zoology); Cell cycle; Cell biology; Cell; Genetics; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009059595,0.0002515288,0.000112248,0.0001798868,0.0001261821,0.0002253802,0.0001229068,0.0002397831,0.001504046],"category_scores_gemma":[0.0000581858,0.0001117549,0.0001448672,0.00007625089,0.0001821336,0.0001245658,0.0002840039,0.0003694732,0.0004408262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002287264,"about_ca_system_score_gemma":0.00009808921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002116027,"about_ca_topic_score_gemma":0.0002704987,"domain_scores_codex":[0.999843,0.00002991415,0.00001001029,0.00003616449,0.00004171786,0.00003912342],"domain_scores_gemma":[0.9999324,0.000007998691,0.00002071553,0.00001194464,0.000006078059,0.00002076411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001778732,0.000005277707,0.0001249839,0.000004966502,0.000001023366,0.00004147668,0.000002702217,0.00001025254,0.9995783,0.00003679017,0.000006105746,0.0001703011],"study_design_scores_gemma":[0.000005734589,0.0001462593,0.004821556,0.000002558986,0.000007779659,0.0008532957,0.00003302953,0.0004754372,0.992465,0.00008123028,0.001105657,0.000002488837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968929,0.000316068,0.00137471,0.00005607314,0.00001076243,0.0000152495,0.00008481378,0.00005682226,0.001192428],"genre_scores_gemma":[0.9978351,0.0001067623,0.0006711159,0.00002898354,0.000001744331,0.000008660303,0.00006305564,0.00000741273,0.001277129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001504046,"threshold_uncertainty_score":0.005031466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01293297678423102,"score_gpt":0.2142064320174683,"score_spread":0.2012734552332373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}