{"id":"W3183702232","doi":"10.1212/nxg.0000000000000605","title":"Disease Severity and Motor Impairment Correlate With Health-Related Quality of Life in AP-4-Associated Hereditary Spastic Paraplegia","year":2021,"lang":"en","type":"article","venue":"Neurology Genetics","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Studienstiftung des Deutschen Volkes; Astellas Pharma; Intellectual and Developmental Disabilities Research Center; Hospital for Sick Children; Deutsche Forschungsgemeinschaft; National Institutes of Health; University of Cambridge; National Institute of Neurological Disorders and Stroke; Quadrant Biosciences; Spastic Paraplegia Foundation; Celgene; Biogen","keywords":"Hereditary spastic paraplegia; Paraplegia; Disease; Medicine; Motor impairment; Spastic; Physical medicine and rehabilitation; Quality of life (healthcare); Pediatrics; Internal medicine; Cerebral palsy; Psychiatry; Spinal cord; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005915516,0.000271978,0.0002581117,0.0007146805,0.0002180929,0.0003915042,0.0001748927,0.0003433498,0.001476487],"category_scores_gemma":[0.00287509,0.000156055,0.0003513074,0.0004514754,0.0003434606,0.0003124144,0.0005296821,0.0003614736,0.0001534769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001855101,"about_ca_system_score_gemma":0.0001311208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001763892,"about_ca_topic_score_gemma":0.001588298,"domain_scores_codex":[0.9996955,0.0001071837,0.0000483245,0.00004169139,0.00005967063,0.00004763632],"domain_scores_gemma":[0.9984025,0.0003142144,0.0008213077,0.00005910077,0.0001389387,0.0002639209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005054442,0.00001399892,0.9989461,0.000004420441,0.00003067297,0.00006981485,0.00003566698,0.00005335659,0.0001673299,0.000004297263,0.00002423626,0.0005994328],"study_design_scores_gemma":[0.000002010237,0.00005522246,0.9994111,0.000002329946,0.00000984266,0.0002869162,0.00004953391,0.0001198296,0.00003035256,0.00001068194,0.00002076817,0.00000149371],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996369,0.0001020091,0.0000382963,0.00001901466,0.000001464093,0.000002344197,0.00004850691,0.00000129692,0.000150294],"genre_scores_gemma":[0.9998251,0.00002091825,0.00002899496,0.000006076966,0.000002648159,0.000001902193,0.00008303919,3.360424e-7,0.00003110948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763892,"threshold_uncertainty_score":0.004939377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03359141474154514,"score_gpt":0.2692310433531692,"score_spread":0.2356396286116241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}