{"id":"W3183702232","doi":"10.1212/nxg.0000000000000605","title":"Disease Severity and Motor Impairment Correlate With Health-Related Quality of Life in AP-4-Associated Hereditary Spastic Paraplegia","year":2021,"lang":"en","type":"article","venue":"Neurology Genetics","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Studienstiftung des Deutschen Volkes; Astellas Pharma; Intellectual and Developmental Disabilities Research Center; Hospital for Sick Children; Deutsche Forschungsgemeinschaft; National Institutes of Health; University of Cambridge; National Institute of Neurological Disorders and Stroke; Quadrant Biosciences; Spastic Paraplegia Foundation; Celgene; Biogen","keywords":"Hereditary spastic paraplegia; Paraplegia; Disease; Medicine; Motor impairment; Spastic; Physical medicine and rehabilitation; Quality of life (healthcare); Pediatrics; Internal medicine; Cerebral palsy; Psychiatry; Spinal cord; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003224784,0.0002795492,0.0006199406,0.00008912705,0.00009749154,0.00001250197,0.0002250293,0.0002068273,0.00008252136],"category_scores_gemma":[0.002138566,0.0002647188,0.00007083312,0.0005151263,0.00052174,0.00005999568,0.0002005714,0.0006408992,0.000009131527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000231065,"about_ca_system_score_gemma":0.0003880886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001165108,"about_ca_topic_score_gemma":0.0003343558,"domain_scores_codex":[0.9953203,0.001991851,0.0008410525,0.0008658968,0.0003750832,0.000605856],"domain_scores_gemma":[0.9978034,0.0008884523,0.0003402365,0.0004400995,0.00006126244,0.0004665435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003078751,0.002297999,0.9771666,0.0002122679,0.00004264985,0.002661399,0.0003646683,0.006227007,0.006915256,0.0001519874,0.0004585953,0.0004228162],"study_design_scores_gemma":[0.001940844,0.001542523,0.9893007,0.00001172014,0.00001799793,0.00003998457,0.00001669728,0.006098253,0.0001092681,0.000677702,0.00003763897,0.0002066511],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926054,0.0007690163,0.0000216789,0.005444415,0.0003919419,0.0004792426,0.0001620221,0.00007488611,0.00005137385],"genre_scores_gemma":[0.99112,0.0003713231,0.00004466957,0.008355384,0.00001779626,0.00002260132,0.00001551202,0.00003095302,0.00002169944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01213412,"threshold_uncertainty_score":0.9999805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03359141474154514,"score_gpt":0.2692310433531692,"score_spread":0.2356396286116241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}