{"id":"W3183731058","doi":"10.1111/ijlh.13605","title":"Gene therapy for hemophilia: Current status and laboratory consequences","year":2021,"lang":"en","type":"review","venue":"International Journal of Laboratory Hematology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Genetic enhancement; Factor IX; Medicine; Clinical trial; Intensive care medicine; Gene delivery; Viral vector; Bioinformatics; Gene; Internal medicine; Biology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006659269,0.0003554391,0.001168449,0.0002917012,0.00005672023,0.00006947921,0.0006219153,0.0003665797,0.00004377212],"category_scores_gemma":[0.0003849718,0.0002980612,0.0003430957,0.0001734105,0.0003310979,0.00001285201,0.000128398,0.0003968429,0.000003573875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008382535,"about_ca_system_score_gemma":0.003977577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.501813e-7,"about_ca_topic_score_gemma":0.00000850076,"domain_scores_codex":[0.9974908,0.0004848213,0.0008984889,0.0004083029,0.0003864497,0.0003311436],"domain_scores_gemma":[0.9959769,0.0001689903,0.0008995048,0.0002793198,0.002478217,0.0001970205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001882919,0.0005337133,0.0002593608,0.002297763,0.005030804,0.0005356829,0.00007698202,0.000004234105,0.01331403,0.001059227,0.009357832,0.9656475],"study_design_scores_gemma":[0.0009591152,0.001002097,0.00000134325,0.0009110295,0.00008873944,0.0004808798,0.00001942014,3.54608e-7,0.01835493,0.00009054031,0.9778352,0.0002562885],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00897304,0.9881729,0.0000664045,0.000175826,0.001526691,0.0003289342,0.0007457617,0.000004833421,0.000005626421],"genre_scores_gemma":[0.0004007295,0.9976695,0.0004231997,0.0002165892,0.0009273138,0.00006086011,0.0002262275,0.00005777188,0.0000178621],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9684774,"threshold_uncertainty_score":0.9999471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04558549477844472,"score_gpt":0.4069646009387833,"score_spread":0.3613791061603386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}