{"id":"W3183731058","doi":"10.1111/ijlh.13605","title":"Gene therapy for hemophilia: Current status and laboratory consequences","year":2021,"lang":"en","type":"review","venue":"International Journal of Laboratory Hematology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Genetic enhancement; Factor IX; Medicine; Clinical trial; Intensive care medicine; Gene delivery; Viral vector; Bioinformatics; Gene; Internal medicine; Biology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00145336,0.001063055,0.001494004,0.001877283,0.0003391126,0.001545344,0.001270083,0.001714828,0.003904161],"category_scores_gemma":[0.001505131,0.0003802851,0.0005081868,0.002181285,0.0009915186,0.00218468,0.0008087129,0.003018538,0.003144776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007941494,"about_ca_system_score_gemma":0.001129188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008576036,"about_ca_topic_score_gemma":0.001300633,"domain_scores_codex":[0.9996586,0.00007276769,0.00004181735,0.00005319403,0.0001402284,0.00003334695],"domain_scores_gemma":[0.9992844,0.0004114937,0.00005844615,0.00002899083,0.0001540715,0.00006256832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009948712,0.00008934321,0.00008624973,0.009244981,0.00003899023,0.0001372273,0.00006971919,0.0003618074,0.001903111,0.006939786,0.04250593,0.9385234],"study_design_scores_gemma":[0.00001920396,0.0000972847,0.0002654853,0.001922828,0.00003963783,0.0005854894,0.00003290196,0.00006101447,0.0004061371,0.002576229,0.9939791,0.00001462304],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006120502,0.9983795,0.0001095228,0.0003191476,0.0002640185,0.00000276891,0.000008236943,0.000008370743,0.0008472626],"genre_scores_gemma":[0.0004056145,0.9982916,0.0001811059,0.0002905891,0.0002162285,0.000006413718,0.00001648656,0.000002962997,0.0005889619],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003904161,"threshold_uncertainty_score":0.01306075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04558549477844472,"score_gpt":0.4069646009387833,"score_spread":0.3613791061603386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}