{"id":"W3183753238","doi":"10.1053/j.gastro.2021.07.009","title":"Anti-Microbial Antibody Response is Associated With Future Onset of Crohn’s Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; Ontario Institute for Cancer Research; McMaster University; University of Alberta; BC Children's Hospital; Stollery Children's Hospital; Hôpital Maisonneuve-Rosemont; Hospital for Sick Children; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Calgary; Population Health Research Institute; Children's Hospital of Eastern Ontario; McGill University Health Centre; University of Ottawa; University of British Columbia; Toronto Western Hospital; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Canada; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Subclinical infection; Inflammation; Disease; Crohn's disease; Immunology; Antibody; Medicine; Barrier function; Function (biology); Inflammatory bowel disease; Biology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007835888,0.0005054346,0.0004970618,0.0009843858,0.00044175,0.0007803746,0.0004481718,0.001315799,0.003859752],"category_scores_gemma":[0.002841719,0.000418108,0.0006862689,0.0008497771,0.0004764212,0.0005181771,0.0003817409,0.001651792,0.0004423399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001759142,"about_ca_system_score_gemma":0.0002426966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001161486,"about_ca_topic_score_gemma":0.001079573,"domain_scores_codex":[0.9993179,0.0002573711,0.00005362057,0.0001521216,0.0001004565,0.0001185479],"domain_scores_gemma":[0.9954695,0.001074628,0.001968234,0.0003076149,0.0002467306,0.0009333762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000614672,0.00009016335,0.9955527,0.00001560197,0.0001219574,0.0002927822,0.00002700292,0.00004359853,0.001900373,0.00003762021,0.0000565138,0.001246921],"study_design_scores_gemma":[0.000005333364,0.0001200748,0.9986094,0.000005434957,0.00004830008,0.0007605137,0.00002740676,0.0001782614,0.0001150175,0.00004186906,0.00008487243,0.000003443439],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976161,0.0008342657,0.00020379,0.0001444224,0.00003032557,0.000003252973,0.0001198178,0.00001208539,0.001036111],"genre_scores_gemma":[0.9991224,0.000169686,0.0001475024,0.0000359882,0.00004055471,0.000002277422,0.00009164518,0.000004239578,0.0003856326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003859752,"threshold_uncertainty_score":0.01291215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00437158656082372,"score_gpt":0.2283585311351105,"score_spread":0.2239869445742867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}