{"id":"W3183753238","doi":"10.1053/j.gastro.2021.07.009","title":"Anti-Microbial Antibody Response is Associated With Future Onset of Crohn’s Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; Ontario Institute for Cancer Research; McMaster University; University of Alberta; BC Children's Hospital; Stollery Children's Hospital; Hôpital Maisonneuve-Rosemont; Hospital for Sick Children; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Mount Sinai Hospital; Princess Margaret Cancer Centre; University of Calgary; Population Health Research Institute; Children's Hospital of Eastern Ontario; McGill University Health Centre; University of Ottawa; University of British Columbia; Toronto Western Hospital; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Canada; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Subclinical infection; Inflammation; Disease; Crohn's disease; Immunology; Antibody; Medicine; Barrier function; Function (biology); Inflammatory bowel disease; Biology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003832015,0.0002002153,0.0003687064,0.00009820986,0.00005032926,0.000007192157,0.0001404461,0.0001940687,0.00006841771],"category_scores_gemma":[0.0004289147,0.0001948521,0.0001456746,0.00008677153,0.000417925,0.000007859197,0.0001589132,0.0001141911,7.848959e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001250193,"about_ca_system_score_gemma":0.0002987468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006529165,"about_ca_topic_score_gemma":0.0001292828,"domain_scores_codex":[0.9976181,0.0008398923,0.0006566296,0.0004207422,0.0001792567,0.0002853282],"domain_scores_gemma":[0.9982097,0.00003725197,0.0005988639,0.0004882639,0.000491761,0.0001741174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02303087,0.0001292004,0.6782734,0.00005048529,0.000504785,0.000155596,0.00004885218,0.00004770605,0.2973929,0.000001215541,0.0003208652,0.00004405055],"study_design_scores_gemma":[0.003247366,0.0006467561,0.9792014,0.00003693744,0.0002863905,0.00004344204,0.00007343203,0.00003637557,0.01623484,0.00001401402,0.00007588746,0.0001031053],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978235,0.0001245965,0.0005285176,0.0001515632,0.0001707948,0.0002072616,0.0009850463,0.000006110243,0.000002650225],"genre_scores_gemma":[0.9989927,0.0001122074,0.0002279107,0.0001393931,0.00008807331,0.000008230417,0.0003843106,0.00002340443,0.00002377136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.300928,"threshold_uncertainty_score":0.7945837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00437158656082372,"score_gpt":0.2283585311351105,"score_spread":0.2239869445742867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}