{"id":"W3183809953","doi":"10.1038/s42003-021-02368-8","title":"Genetic architecture of type 1 diabetes with low genetic risk score informed by 41 unreported loci","year":2021,"lang":"en","type":"article","venue":"Communications Biology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; Children's Hospital of Philadelphia","keywords":"Genetic architecture; Single-nucleotide polymorphism; Genetics; Type 1 diabetes; Autism; Genome-wide association study; Biology; Gene; Genetic association; Case-control study; Diabetes mellitus; Genotype; Medicine; Internal medicine; Quantitative trait locus; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007751244,0.000605871,0.0006027886,0.002220307,0.0008921942,0.001086627,0.0005961549,0.000816435,0.004120414],"category_scores_gemma":[0.003185972,0.0003366848,0.0008268062,0.002172926,0.00064957,0.0002628877,0.0007947308,0.0007122491,0.0002763597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002670825,"about_ca_system_score_gemma":0.0002732242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002256942,"about_ca_topic_score_gemma":0.001684105,"domain_scores_codex":[0.9985355,0.0004463383,0.0001900989,0.0004849842,0.0001836605,0.000159419],"domain_scores_gemma":[0.9980379,0.0007182651,0.0007433771,0.0001919957,0.0001064523,0.0002020276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009330788,0.0000644,0.9854033,0.00002545844,0.000319717,0.003571054,0.0002608421,0.0002148912,0.004080814,0.0003373942,0.0001342036,0.004654862],"study_design_scores_gemma":[0.00007964927,0.0001900177,0.9873776,0.00003292537,0.0003976525,0.007972668,0.0002702298,0.001269382,0.0008600765,0.001019827,0.0004997678,0.00003017385],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990131,0.0001922669,0.000274052,0.00004050753,0.000005555486,0.000005600596,0.0001173779,0.000007179274,0.000344321],"genre_scores_gemma":[0.9994356,0.00006346839,0.0001907559,0.00001984097,0.000008365305,0.000004231853,0.000146696,0.000004687993,0.0001263943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004120414,"threshold_uncertainty_score":0.01378417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007874386581502845,"score_gpt":0.2410460957918633,"score_spread":0.2331717092103604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}