{"id":"W3183822763","doi":"10.1016/j.bbiosy.2021.100021","title":"Polymeric siRNA delivery targeting integrin-β1 could reduce interactions of leukemic cells with bone marrow microenvironment","year":2021,"lang":"en","type":"article","venue":"Biomaterials and Biosystems","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"K562 cells; Integrin; Cancer research; Bone marrow; Stromal cell; Cell biology; Small interfering RNA; Fibronectin; Chemistry; Cell; Cell culture; Extracellular matrix; Biology; Immunology; Transfection; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007706736,0.0003263767,0.0001735276,0.0001694196,0.00007994723,0.0001777962,0.00009854579,0.0002201997,0.0007207536],"category_scores_gemma":[0.00007467861,0.0001095646,0.0001382387,0.00009638325,0.0001111786,0.0001292195,0.0001140796,0.0002326582,0.0001404774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001660942,"about_ca_system_score_gemma":0.000137213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004579513,"about_ca_topic_score_gemma":0.0007592801,"domain_scores_codex":[0.9999405,0.000007830122,0.000004237166,0.00001458347,0.00001822849,0.00001453492],"domain_scores_gemma":[0.9999776,0.000005032594,0.000007313301,0.00000188829,0.000004354167,0.00000380983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002992204,0.00001287813,0.00005105195,0.00003397357,0.000002916735,0.00001435371,0.000007689917,0.00004831783,0.9978079,0.00005524345,0.00002843735,0.00190715],"study_design_scores_gemma":[0.000009827842,0.0002303226,0.00101268,0.000003496541,0.00001606258,0.00005531777,0.000007616482,0.0006149863,0.9958597,0.00001648417,0.002171772,0.000001777771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890596,0.002917718,0.005699107,0.00009760702,0.0000411832,0.0000556821,0.0001022135,0.00008109853,0.001945858],"genre_scores_gemma":[0.9925815,0.001600308,0.002745588,0.00005771593,0.000008906521,0.00005765157,0.0001559462,0.00001530519,0.002777105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007207536,"threshold_uncertainty_score":0.002411127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258784923619327,"score_gpt":0.2340241406410625,"score_spread":0.2214362914048692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}