{"id":"W3183902111","doi":"10.3389/fphys.2021.683651","title":"ETS1, ELK1, and ETV4 Transcription Factors Regulate Angiopoietin-1 Signaling and the Angiogenic Response in Endothelial Cells","year":2021,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada); McGill University Health Centre","funders":"Canadian Institutes of Health Research; Instituto para la Formación y Aprovechamiento de Recursos Humanos; McGill University","keywords":"ETS1; Transcription factor; Gene knockdown; Cell biology; Biology; Chromatin immunoprecipitation; Chemistry; Gene expression; Promoter; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269678,0.0003665765,0.0002133991,0.0002771808,0.0002065209,0.0003046522,0.0001976611,0.0002072911,0.001865194],"category_scores_gemma":[0.0001151557,0.0001334765,0.0003170381,0.000184457,0.0002055385,0.0002612638,0.0002164305,0.0003531092,0.0006649044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004406237,"about_ca_system_score_gemma":0.0002719388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008321655,"about_ca_topic_score_gemma":0.001005567,"domain_scores_codex":[0.9998661,0.00001475659,0.000007354687,0.00003128225,0.00004119019,0.00003916316],"domain_scores_gemma":[0.9999231,0.00001074866,0.00002746989,0.000005072451,0.00001583282,0.00001780658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002792353,0.00003077524,0.003111115,0.000119595,0.00001623132,0.00007642507,0.00003034076,0.0003466609,0.9914883,0.0002021147,0.0001417762,0.00415744],"study_design_scores_gemma":[0.00003119997,0.0001575809,0.07667919,0.00002394289,0.00005388501,0.0004564928,0.0001268507,0.003095355,0.9112592,0.0003318976,0.007766142,0.00001835096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869022,0.005969927,0.003974573,0.0001309519,0.00003009606,0.00002579984,0.001023259,0.00009319772,0.001849849],"genre_scores_gemma":[0.9889848,0.002634871,0.002558772,0.00006137496,0.00001386231,0.00003254667,0.001466645,0.00002607013,0.004220943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001865194,"threshold_uncertainty_score":0.006239772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00714943046619231,"score_gpt":0.2166777042106975,"score_spread":0.2095282737445052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}