{"id":"W3183942893","doi":"10.1158/2159-8290.cd-21-0177","title":"Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; New York State Stem Cell Science; Université de Recherche Paris Sciences et Lettres; National Institutes of Health; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; Fondation du Collège de France; European Commission; Centre National de la Recherche Scientifique","keywords":"Venetoclax; Mitochondrion; Biogenesis; Mitochondrial biogenesis; Senescence; Dual role; Myeloid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001422436,0.0002622711,0.0004911562,0.0001928009,0.00007011463,0.00007486611,0.0002644079,0.0001535503,0.0004294854],"category_scores_gemma":[0.0002511366,0.0002323984,0.0001303481,0.0008583031,0.0000904384,0.0003347811,0.0001753499,0.0005666501,0.0001081152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001513595,"about_ca_system_score_gemma":0.002557476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008251269,"about_ca_topic_score_gemma":0.0007390525,"domain_scores_codex":[0.9976524,0.0001279922,0.0003234766,0.0007203449,0.0005158175,0.0006599596],"domain_scores_gemma":[0.9985254,0.0001236929,0.00006579902,0.0007695748,0.0001968375,0.0003187008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001454252,0.0002197902,0.1574131,0.000116428,0.000118537,0.001317517,0.00148065,0.0001822686,0.7888623,0.00009688317,0.03696426,0.01177404],"study_design_scores_gemma":[0.005878887,0.0002586998,0.3527705,0.0008049111,0.00003694168,0.00008763331,0.001021907,0.0002834557,0.5590527,0.00005133666,0.07918587,0.0005671841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824462,0.00378286,0.0005102418,0.009694516,0.0007196052,0.0008416859,0.00005506722,0.00005630854,0.00189355],"genre_scores_gemma":[0.9737723,0.002930154,0.002215805,0.004038701,0.0009104956,0.0003583189,0.00007923851,0.00008233199,0.01561258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2298096,"threshold_uncertainty_score":0.9476932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03330317864172556,"score_gpt":0.3377624613201965,"score_spread":0.3044592826784709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}