{"id":"W3183942893","doi":"10.1158/2159-8290.cd-21-0177","title":"Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; New York State Stem Cell Science; Université de Recherche Paris Sciences et Lettres; National Institutes of Health; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche; Fondation du Collège de France; European Commission; Centre National de la Recherche Scientifique","keywords":"Venetoclax; Mitochondrion; Biogenesis; Mitochondrial biogenesis; Senescence; Dual role; Myeloid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001044169,0.0001923758,0.0001719376,0.000245002,0.0001784938,0.000231612,0.0001955896,0.0002291186,0.0009383175],"category_scores_gemma":[0.00009771987,0.00007089516,0.000123505,0.0001469813,0.0002029219,0.0001064501,0.0001674936,0.0005761514,0.0002215707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003824127,"about_ca_system_score_gemma":0.0002989506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004169305,"about_ca_topic_score_gemma":0.0007286963,"domain_scores_codex":[0.9999373,0.00001289161,0.000006827082,0.00001458542,0.00001475236,0.0000135894],"domain_scores_gemma":[0.9999489,0.00000846084,0.00001615919,0.00000823399,0.000005606269,0.0000126393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004170175,0.0001240345,0.0003158642,0.00007832718,0.000008342725,0.00007153377,0.00001715532,0.0002604912,0.9861895,0.0003235435,0.0002233299,0.01197095],"study_design_scores_gemma":[0.000172377,0.001325786,0.003507934,0.00001117799,0.00002564238,0.0006529599,0.00001315687,0.001360479,0.9803217,0.0001142548,0.01248815,0.000006395896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872862,0.004875519,0.003536223,0.0003526656,0.0001169841,0.0001353693,0.0003351467,0.0003148496,0.003047079],"genre_scores_gemma":[0.9949222,0.001568537,0.001644736,0.00005213394,0.00002179594,0.00005001227,0.0002201514,0.00001181965,0.001508482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009383175,"threshold_uncertainty_score":0.003139019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03330317864172556,"score_gpt":0.3377624613201965,"score_spread":0.3044592826784709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}