{"id":"W3184017634","doi":"10.2139/ssrn.3396011","title":"Cell-Free DNA Levels of Twins and Sibling Pairs Indicate Individuality and Possible Use As a Personalized Biomarker","year":2019,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Biomarker; Sibling; Genetics; Computational biology; DNA; Cell-free fetal DNA; Biology; Psychology; Computer science; Developmental psychology; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003022495,0.0002579803,0.0003221136,0.0008540054,0.0003321097,0.0004513999,0.0002084418,0.0004122063,0.002563925],"category_scores_gemma":[0.001133562,0.0001877156,0.0002017372,0.0005516825,0.0002659497,0.0002083752,0.0003701933,0.0003602584,0.0005901569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001130375,"about_ca_system_score_gemma":0.0001599517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001198365,"about_ca_topic_score_gemma":0.00174224,"domain_scores_codex":[0.9996778,0.00008666204,0.00001818553,0.0001133373,0.00006990651,0.00003407686],"domain_scores_gemma":[0.9995673,0.0001199029,0.0000959127,0.000067578,0.00006285509,0.00008648462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001169562,0.000145879,0.3585668,0.00006812122,0.0002374214,0.0003567275,0.000850971,0.0001287857,0.6256422,0.0004137759,0.0002582745,0.01216155],"study_design_scores_gemma":[0.00002007909,0.001144501,0.8254415,0.00001584625,0.0002753345,0.0027383,0.0009795771,0.0006012973,0.1657367,0.0008263239,0.002199224,0.00002126895],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960311,0.0004236606,0.001618133,0.00003688961,0.00002248235,0.00001175997,0.0008100292,0.0000156365,0.001030295],"genre_scores_gemma":[0.9958763,0.0002417125,0.001222417,0.00003587455,0.000009600772,0.00001672685,0.0008390806,0.000009491055,0.001748755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002563925,"threshold_uncertainty_score":0.008577168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488145421836194,"score_gpt":0.25055403644696,"score_spread":0.235672582228598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}