{"id":"W3184055995","doi":"","title":"A Hybrid Human/Mouse T4K Rhodopsin Transgene Causes Light Exacerbated Retinal Degeneration Indistinguishable from Human T4K Rhodopsin","year":2020,"lang":"en","type":"article","venue":"","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Rhodopsin; Retinal degeneration; Transgene; Retinal; Degeneration (medical); Visual phototransduction; Biology; Cell biology; Retina; Neuroscience; Ophthalmology; Medicine; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004939846,0.0009981275,0.0004995082,0.001025109,0.0005599508,0.0006791956,0.0006901822,0.001133064,0.006279542],"category_scores_gemma":[0.0003214178,0.0006297877,0.0008617497,0.0004711472,0.001415271,0.0005684098,0.0005968949,0.001650993,0.001702573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008316883,"about_ca_system_score_gemma":0.0009828869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004042329,"about_ca_topic_score_gemma":0.004309813,"domain_scores_codex":[0.9992664,0.00006013185,0.0001100112,0.0001805006,0.0002071962,0.0001756797],"domain_scores_gemma":[0.9990761,0.0001618521,0.0002607642,0.0001067268,0.00005138811,0.0003431948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002437127,0.00005413408,0.00006978432,0.00001638845,0.00001541649,0.0002604842,0.00002300532,0.00004783566,0.9987282,0.0002709124,0.00005673555,0.0002134122],"study_design_scores_gemma":[0.0001192139,0.0003296015,0.002757254,0.00001067274,0.00005831633,0.001782203,0.00009029419,0.00109963,0.9911017,0.0001842089,0.002449206,0.00001767236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880897,0.000380659,0.004952217,0.0002931037,0.0002040488,0.0001224976,0.001697213,0.0003747489,0.003885737],"genre_scores_gemma":[0.9793524,0.0004381879,0.00532869,0.0001726655,0.00003447427,0.0001341667,0.001635515,0.0004291632,0.01247474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006279542,"threshold_uncertainty_score":0.02100712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1097374630875878,"score_gpt":0.3274298644167748,"score_spread":0.217692401329187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}