{"id":"W3184057921","doi":"10.3389/fcell.2021.657406","title":"Aberrant Autophagy Impacts Growth and Multicellular Development in a Dictyostelium Knockout Model of CLN5 Disease","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trent University","funders":"Canadian Institutes of Health Research","keywords":"Batten disease; Biology; Cell biology; Dictyostelium; Autophagy; Chemotaxis; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003260352,0.0008134422,0.0004734071,0.0008547478,0.0003453644,0.0003560144,0.000512389,0.00111533,0.001441319],"category_scores_gemma":[0.0002381442,0.0003681724,0.0004744963,0.0002572646,0.0005688756,0.0003721189,0.0004015162,0.001058263,0.0005192299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009590399,"about_ca_system_score_gemma":0.0004583276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002612452,"about_ca_topic_score_gemma":0.003896453,"domain_scores_codex":[0.999559,0.00006120747,0.00009183004,0.0001023304,0.00009665298,0.00008893957],"domain_scores_gemma":[0.9994788,0.00006447041,0.0001484304,0.00003513502,0.00003694968,0.0002363131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003548636,0.00009648942,0.0002615236,0.00004922279,0.000009334989,0.0002494196,0.00005125179,0.0001417626,0.9980606,0.0001461882,0.00007923262,0.0005000542],"study_design_scores_gemma":[0.0001992284,0.001499763,0.01103111,0.00005551027,0.00008684622,0.001264173,0.0001942624,0.006020808,0.9753998,0.0002017102,0.004014602,0.0000323114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994377,0.0008292533,0.001835803,0.0002269847,0.00006273094,0.00006091444,0.001200694,0.0001366894,0.001269991],"genre_scores_gemma":[0.9910232,0.0004922658,0.002478705,0.000127501,0.00001124215,0.0001074133,0.0008484299,0.00006999887,0.004841209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002612452,"threshold_uncertainty_score":0.006958365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01681096015243243,"score_gpt":0.2527018121640297,"score_spread":0.2358908520115973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}