{"id":"W3184094437","doi":"10.1016/j.neulet.2021.136114","title":"Nicotine prevents in vivo Aβ toxicity in Caenorhabditis elegans via SKN-1","year":2021,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; Chinese Academy of Sciences","keywords":"Nicotine; Caenorhabditis elegans; Oxidative stress; Neurotoxicity; In vivo; Reactive oxygen species; Toxicity; Pharmacology; Biology; Transgene; RNA interference; Cell biology; Chemistry; Biochemistry; Neuroscience; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655029,0.0001623535,0.0001531936,0.00007348014,0.00005895063,0.00004432104,0.0003488854,0.0000871331,0.00002374656],"category_scores_gemma":[0.0001105287,0.0001853163,0.00005616927,0.0003072148,0.0001358699,0.00001111054,0.0001725843,0.000175117,0.000004193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002922791,"about_ca_system_score_gemma":0.00006820841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001023501,"about_ca_topic_score_gemma":0.0007573357,"domain_scores_codex":[0.9983393,0.0001136764,0.0002411274,0.0006431044,0.0002218933,0.0004408836],"domain_scores_gemma":[0.999427,0.00000884479,0.00005652276,0.0004020598,0.00002194345,0.00008364204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004947262,0.0001002835,0.04278423,0.000009179269,9.352711e-7,0.00005076707,0.0001209256,0.001111553,0.9549252,0.000003246549,0.0006978682,0.0001909133],"study_design_scores_gemma":[0.0003796909,0.00007812877,0.03654091,0.00001178104,0.000003139187,0.00004234294,0.00001669521,0.0004860902,0.9568642,0.00002419497,0.005344677,0.0002081806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992907,0.0000591652,0.003746527,0.00251589,0.0005050243,0.0001252223,0.00001158671,0.000009832208,0.0001197214],"genre_scores_gemma":[0.9857816,0.00007793078,0.0003789923,0.01328208,0.00009970435,0.00001002062,0.000009219154,0.00001819242,0.0003422177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0107662,"threshold_uncertainty_score":0.7556978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008292443448013075,"score_gpt":0.2265061346722305,"score_spread":0.2182136912242174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}