{"id":"W3184111626","doi":"10.1002/arch.21834","title":"Silencing of an ABC transporter, but not a cadherin, decreases the susceptibility of Colorado potato beetle larvae to <i>Bacillus thuringiensis</i> ssp. <i>tenebrionis</i> Cry3Aa toxin","year":2021,"lang":"en","type":"article","venue":"Archives of Insect Biochemistry and Physiology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Agriculture and Agri-Food Canada","funders":"Max-Planck-Gesellschaft","keywords":"Colorado potato beetle; Bacillus thuringiensis; Leptinotarsa; Biology; ATP-binding cassette transporter; Gene silencing; Toxin; Mode of action; Microbiology; PEST analysis; Larva; Gene; Transporter; Botany; Genetics; Bacteria; Toxicology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006504975,0.0001805563,0.000245289,0.000107621,0.0001198084,0.0002442717,0.0002094816,0.0002726936,0.001156121],"category_scores_gemma":[0.00007969133,0.0001223071,0.0001354987,0.00007011452,0.0001502307,0.0001150937,0.0001272049,0.0004536597,0.0002633101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002872504,"about_ca_system_score_gemma":0.0001709342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002062543,"about_ca_topic_score_gemma":0.003432045,"domain_scores_codex":[0.9999069,0.000009555687,0.000008441893,0.00002481835,0.00002184723,0.00002850095],"domain_scores_gemma":[0.999898,0.00001805001,0.00003176609,0.000006860256,0.00001116463,0.00003404454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004364985,0.00001248012,0.0001489202,0.00001702653,0.000002824835,0.00001151977,0.000008966456,0.00001493275,0.9993725,0.00001503889,0.0000242375,0.000327891],"study_design_scores_gemma":[0.00004380863,0.0005627412,0.03755471,0.00001222236,0.00004082464,0.0002213495,0.0001196688,0.002319932,0.9555209,0.00002336951,0.003568638,0.00001189568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979772,0.0005237423,0.000410362,0.00006141402,0.0000114259,0.000008646804,0.0001595828,0.00004509927,0.0008025129],"genre_scores_gemma":[0.9966162,0.0003067452,0.0004845046,0.00008019697,0.00000452698,0.00002046499,0.0004168673,0.00001997235,0.002050575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002062543,"threshold_uncertainty_score":0.004101098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008487524060576679,"score_gpt":0.2232106695980851,"score_spread":0.2147231455375084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}