{"id":"W3184111626","doi":"10.1002/arch.21834","title":"Silencing of an ABC transporter, but not a cadherin, decreases the susceptibility of Colorado potato beetle larvae to <i>Bacillus thuringiensis</i> ssp. <i>tenebrionis</i> Cry3Aa toxin","year":2021,"lang":"en","type":"article","venue":"Archives of Insect Biochemistry and Physiology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Agriculture and Agri-Food Canada","funders":"Max-Planck-Gesellschaft","keywords":"Colorado potato beetle; Bacillus thuringiensis; Leptinotarsa; Biology; ATP-binding cassette transporter; Gene silencing; Toxin; Mode of action; Microbiology; PEST analysis; Larva; Gene; Transporter; Botany; Genetics; Bacteria; Toxicology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135124,0.0002214508,0.0003993571,0.00002428687,0.0000918985,0.000005953539,0.0002857786,0.0001451704,0.00001533394],"category_scores_gemma":[0.0001039781,0.0001897649,0.0001819046,0.0001130073,0.0005799585,0.000004865716,0.0001442437,0.0001134675,2.762468e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004277485,"about_ca_system_score_gemma":0.0001869999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000190266,"about_ca_topic_score_gemma":0.000328621,"domain_scores_codex":[0.9985541,0.0001250466,0.0004360475,0.0004905435,0.0001173094,0.000277007],"domain_scores_gemma":[0.9988142,0.000103997,0.0001943981,0.0006327603,0.0001373029,0.0001173343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009794977,0.0002544346,0.0006397004,0.0003069416,0.00008982998,0.000005507909,0.0004478862,0.0001619265,0.9958782,0.00001892761,0.0000208129,0.001196338],"study_design_scores_gemma":[0.0004853219,0.0007107366,0.01884715,0.00004913867,0.00004414681,0.00002871981,0.0005266481,0.00002134497,0.978684,0.0002336186,0.0001790224,0.0001901434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979619,0.001201957,0.00008359354,0.00005468405,0.00004218828,0.0001403841,0.0002952896,0.000005579666,0.0002144266],"genre_scores_gemma":[0.9977923,0.0005352778,0.001037576,0.0002725557,0.00008418338,0.00001262972,0.0001825639,0.00001626639,0.00006663079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01820745,"threshold_uncertainty_score":0.7738389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008487524060576679,"score_gpt":0.2232106695980851,"score_spread":0.2147231455375084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}