{"id":"W3184115587","doi":"10.3390/vaccines9080823","title":"Critical Assessment of Purification and Analytical Technologies for Enveloped Viral Vector and Vaccine Processing and Their Current Limitations in Resolving Co-Expressed Extracellular Vesicles","year":2021,"lang":"en","type":"review","venue":"Vaccines","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Viral envelope; Viral vector; Biology; Virology; Context (archaeology); Computational biology; Extracellular vesicles; Biogenesis; Viral entry; Extracellular vesicle; Vector (molecular biology); Virotherapy; Microvesicles; Virus; Oncolytic virus; Viral replication; Cell biology; Gene; Genetics; microRNA; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002014713,0.001083888,0.001217445,0.002120394,0.0003141889,0.001471865,0.001029182,0.001208342,0.002630583],"category_scores_gemma":[0.001693079,0.0005560772,0.0007809745,0.001875977,0.0005749788,0.002285059,0.0007845871,0.002392888,0.002208657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001076297,"about_ca_system_score_gemma":0.002055952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001109556,"about_ca_topic_score_gemma":0.001361745,"domain_scores_codex":[0.9993922,0.0001191176,0.00007793017,0.0001016682,0.0002481628,0.00006096752],"domain_scores_gemma":[0.9991472,0.0004492647,0.00008586809,0.00003715049,0.0002446807,0.00003589798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008555239,0.00009972342,0.0002244841,0.02940056,0.0001226693,0.0003035775,0.0001491538,0.001153191,0.0170551,0.01881693,0.01718279,0.9154062],"study_design_scores_gemma":[0.00001039011,0.0001674847,0.0004631771,0.002860134,0.0001041787,0.0009457282,0.00006671026,0.0003012232,0.007154625,0.002561388,0.9853292,0.00003585498],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004989494,0.9945229,0.001900218,0.0003590564,0.0003395601,0.00001918535,0.00004322905,0.00002329172,0.002293549],"genre_scores_gemma":[0.001615349,0.9946108,0.00226683,0.0002291271,0.0001372456,0.0000304907,0.00008808736,0.000008489406,0.001013569],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002630583,"threshold_uncertainty_score":0.01065493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06260845267940941,"score_gpt":0.3737298097480602,"score_spread":0.3111213570686508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}