{"id":"W3184115587","doi":"10.3390/vaccines9080823","title":"Critical Assessment of Purification and Analytical Technologies for Enveloped Viral Vector and Vaccine Processing and Their Current Limitations in Resolving Co-Expressed Extracellular Vesicles","year":2021,"lang":"en","type":"review","venue":"Vaccines","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Viral envelope; Viral vector; Biology; Virology; Context (archaeology); Computational biology; Extracellular vesicles; Biogenesis; Viral entry; Extracellular vesicle; Vector (molecular biology); Virotherapy; Microvesicles; Virus; Oncolytic virus; Viral replication; Cell biology; Gene; Genetics; microRNA; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002819664,0.0002946455,0.0006987111,0.0001579988,0.00007925158,0.00007674943,0.0001402035,0.0002594457,0.000001129729],"category_scores_gemma":[0.001122453,0.0002463917,0.00009214116,0.0001410252,0.00009130147,0.00001614592,0.0001589495,0.00016968,5.833095e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001661711,"about_ca_system_score_gemma":0.0001869548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.015235e-7,"about_ca_topic_score_gemma":0.000004128327,"domain_scores_codex":[0.9984598,0.0001157526,0.0005519341,0.0005888412,0.00007604647,0.0002076176],"domain_scores_gemma":[0.9990394,0.0002744945,0.0001882457,0.0002964179,0.0001406495,0.00006078209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002295268,0.000183873,0.0005708215,0.01265935,0.00006348455,0.000003445324,0.00004225722,8.440094e-7,0.02878657,0.001028029,0.00006535667,0.956573],"study_design_scores_gemma":[0.003727665,0.0009047692,0.008491333,0.02365946,0.002220291,0.000126358,0.001972351,0.01099621,0.03727876,0.002055523,0.9058623,0.002704958],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01356469,0.9826501,0.002919837,0.0001307115,0.00003063029,0.0005928093,0.00008360468,0.00001815962,0.000009467462],"genre_scores_gemma":[0.09239234,0.9030376,0.003971155,0.000002612582,0.00006044446,0.0001943129,0.0002887298,0.00003557226,0.00001724386],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.953868,"threshold_uncertainty_score":0.9999988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06260845267940941,"score_gpt":0.3737298097480602,"score_spread":0.3111213570686508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}